Last update :
21/01/2021
References   References 1501  
Type : Journal

Research teams : Mannheim - Fakultät für Klinische Medizin Mannheim der Universität Heidelberg
Authors : Beitz C, Bertsch T, Hannak D, Schrammel W, Einberger C, Wehling M.
Title : Compatibility of plastics with cytotoxic drug solutions - comparison of polyethylene with other container materials.
Reference : Int J Pharm ; 185: 113-121. 1999

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Degradation products detected but not quantified

List of drugs
InjectionCarmustine Anticancer drug
Stability in solutions Glass Glucose 5% 0,2 mg/ml 23°C Protect from light
5.5 Hour
Stability in solutions Glass Glucose 5% 0,2 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Polyethylene Glucose 5% 0,2 mg/ml 23°C Protect from light
2.5 Hour
Stability in solutions Polyethylene Glucose 5% 0,2 mg/ml 4°C Protect from light
72 Hour
InjectionCytarabine Anticancer drug
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,144 mg/ml 23°C Protect from light
72 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,144 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,144 mg/ml 23°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,144 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,144 mg/ml 23°C Protect from light
72 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,144 mg/ml 4°C Protect from light
72 Hour
InjectionDacarbazine Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 0,64 mg/ml 23°C Protect from light
48 Hour
Stability in solutions Glass Sodium chloride 0,9% 0,64 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,64 mg/ml 23°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,64 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 0,64 mg/ml 23°C Protect from light
48 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 0,64 mg/ml 4°C Protect from light
48 Hour
InjectionFluorouracil Anticancer drug
Stability in solutions Glass NaCl 0,9% or Glucose 5% 1,44 mg/ml 23°C Protect from light
72 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 1,44 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,44 mg/ml 23°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,44 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 1,44 mg/ml 23°C Protect from light
72 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 1,44 mg/ml 4°C Protect from light
72 Hour
InjectionGemcitabine hydrochloride Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 5,12 mg/ml 23°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 5,12 mg/ml 23°C Protect from light
48 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 5,12 mg/ml 23°C Protect from light
48 Hour
InjectionMelphalan Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 0,06 mg/ml 23°C Protect from light
1 Hour
Stability in solutions Glass Sodium chloride 0,9% 0,06 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,06 mg/ml 23°C Protect from light
1 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,06 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 0,06 mg/ml 23°C Protect from light
1 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 0,06 mg/ml 4°C Protect from light
24 Hour
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,36 mg/ml 23°C Protect from light
72 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,36 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,36 mg/ml 23°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,36 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,36 mg/ml 23°C Protect from light
72 Hour
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,36 mg/ml 4°C Protect from light
72 Hour
InjectionVinorelbine tartrate Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 0,385 mg/ml 23°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,385 mg/ml 23°C Protect from light
7 Day
Stability in solutions Polyethylene Sodium chloride 0,9% 0,385 mg/ml 23°C Protect from light
7 Day

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