Last update :
22/01/2021
References   References 1021  
Type : Journal

Research teams : Alesund - Hospital of Alesund, Pharmacy Department
Authors : Dyvik O, Grislingaas AL, Tonnesen HH, Karlsen J.
Title : Methotrexate in solutions - A stability test for the hospital pharmacy.
Reference : J Clin Hosp Pharm ; 11: 343-348. 1986

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products

List of drugs
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 & 20 mg/ml -20°C Protect from light
84 Day

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