Last update :
21/01/2021
References   References 3980  
Type : Journal
Web link : https://doi.org/10.2146/ajhp150818

Research teams : Odense - Odense University Hospital, Hospital Pharmacy
Authors : Nissen K.B, Jorgensen L.B, Berg D.L, Andersen G.
Title : Stability study of methotrexate in 0.9% sodium chloride injection and 5% dextrose injection with limit tests for impurities.
Reference : Am J Health-Syst Pharm ; 74,9: e211-e223 2017

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Water loss by evaporation 
Comments : 
Degradation products identified

List of drugs
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 0,2 mg/ml 23-27°C Protect from light
28 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 23-27°C Protect from light
28 Day
Stability in solutions Polyolefine Glucose 5% 0,2 mg/ml 23-27°C Protect from light
3 Day
Stability in solutions Polyolefine Glucose 5% 20 mg/ml 23-27°C Protect from light
28 Day

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