Last update :
29/11/2021
References   References 739  
Type : Journal

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Cradock JC, Kleinmann LM, Rahman A.
Title : Evaluation of some pharmaceutical aspects of intrathecal methotrexate sodium, cytarabine and hydrocortisone sodium succinate.
Reference : Am J Hosp Pharm ; 35: 402-406. 1978

Level of Evidence : 
Joker
Level of Evidence : 
Level of evidence C Cytarabine
Level of evidence C Methotrexate sodium
Level of evidence D Hydrocortisone sodium succinate
Physical stability : 
Chemical stability : 
Thin Layer ChromatographyCytarabine
Stability defined as 95% of the initial concentrationCytarabine
Thin Layer ChromatographyMethotrexate sodium
Stability defined as 95% of the initial concentrationMethotrexate sodium
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Hydrocortisone sodium succinate
Stability defined as 90% of the initial concentrationHydrocortisone sodium succinate
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified valuesCytarabine
Repeatability / reproducibility / standard range: results not provided or results outside specified valuesMethotrexate sodium
Repeatability / reproducibility / standard range: results not provided or results outside specified valuesHydrocortisone sodium succinate

List of drugs
InjectionCytarabine Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 5 mg/ml 25°C Light
7 Day
Stability in solutions Glass Ringer’s lactate solution 5 mg/ml 25°C Light
7 Day
Stability in solutions Glass Elliott’s B solution 5 mg/ml 25°C Light
7 Day
InjectionHydrocortisone sodium succinate Anti-inflammatory
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 25°C Light
3 Day
Stability in solutions Glass Ringer’s lactate solution 1 mg/ml 25°C Light
3 Day
Stability in solutions Glass Elliott’s B solution 1 mg/ml 25°C Light
24 Hour
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 2,5 mg/ml 25°C Light
7 Day
Stability in solutions Glass Ringer’s lactate solution 2,5 mg/ml 25°C Light
7 Day
Stability in solutions Glass Elliott’s B solution 2,5 mg/ml 25°C Light
7 Day

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