Last update :
19/10/2020
References   References 3670  
Type : Journal
Web link : http://www.esop.li/ejop.php

Research teams : Plymouth - Plymouth University, School of Health Professions
Authors : Sewell G, Massimini M.
Title : Studies on the stability and compatibility of cytotoxic drug infusion with the Tevadaptor system.
Reference : EJOP ; 8, 3: 26-30. 2014

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Water loss by evaporation 
Comments : 

List of drugs
InjectionCarboplatin Anticancer drug
Stability in solutions Polyolefine Glucose 5% 2 mg/ml 2-8°C Protect from light
84 Day
InjectionCisplatin Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 0.5 mg/ml 2-8°C Protect from light
28 Day
InjectionDoxorubicin hydrochloride Anticancer drug
Stability in solutions Polypropylen Syringe None 2 mg/ml 2-8°C Protect from light
84 Day
InjectionEpirubicin hydrochloride Anticancer drug
Stability in solutions Polypropylen Syringe None 2 mg/ml 2-8°C Protect from light
84 Day
InjectionEtoposide Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 0.25 mg/ml 20°C Protect from light
5 Day
InjectionFludarabine phosphate Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 0.15 mg/ml 2-8°C Protect from light
14 Day
InjectionFluorouracil Anticancer drug
Stability in solutions Polypropylen Syringe None 25 mg/ml 2-8°C Protect from light
84 Day
InjectionGemcitabine hydrochloride Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 9 mg/ml 2-8°C Protect from light
84 Day
InjectionIrinotecan Anticancer drug
Stability in solutions Polyolefine Sodium chloride 0,9% 1 mg/ml 2-8°C Protect from light
84 Day
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Polypropylen Syringe None 25 mg/ml 2-8°C Protect from light
84 Day
InjectionOxaliplatin Anticancer drug
Stability in solutions Polyolefine Glucose 5% 1.5 mg/ml 2-8°C Protect from light
84 Day

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