Last update :
21/01/2021
References   References 162  
Type : Journal

Research teams : Lille - Faculté des Sciences Pharmaceutiques et Biologiques
Authors : Benaji B, Dine T, Goudaliez F, Luyckx M, Brunet C, Mallevais ML, Gressier B, Cazin M, Cazin JC.
Title : Compatibility study of methotrexate with PVC bags after repackaging into two types of infusion admixtures.
Reference : Int J Pharm ; 105: 83-87. 1994

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Degradation products not observed in real conditions

List of drugs
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,225 mg/ml 4°C Protect from light
30 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 24 mg/ml 4°C Protect from light
30 Day

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