Last update :
17/04/2024
References   References 619  
Type : Journal

Research teams : Brooklyn - Long Island University, Arnold and Marie Schwarz College of Pharmacy
Authors : Kirschenbaum HL, Aronoff W, Perentesis GP, Plitz GW, Cutie AJ.
Title : Stability and compatibility of lidocaine hydrochloride with selected large-volume parenterals and drugs additives.
Reference : Am J Hosp Pharm ; 39: 1013-1015. 1982

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Ultraviolet spectrometry
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Method not shown but the article refers to a validated method
Stability indicating capability inadequately assessed

List of drugs
InjectionAminophylline Various
Compatible 1 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
InjectionBretylium tosilate Anti-arrhythmic
Compatible 1 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
InjectionCalcium gluconate Electrolyte
Compatible 2 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
InjectionDigoxin Cardiotonic
Compatible 1 µg/ml + InjectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 µg/ml + InjectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
InjectionDopamine hydrochloride Cardiotonic
Compatible 0.8 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.8 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
InjectionInsulin Glucose-lowering
Compatible 1 UI/ml + InjectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + InjectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
InjectionLidocaine hydrochloride Local anesthetic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 2 mg/ml 25°C Light
14 Day
Stability in solutions Glass Ringer’s lactate solution 2 mg/ml 25°C Light
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 2 mg/ml 25°C Light
14 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 2 mg/ml 25°C Light
14 Day
Compatible 2 mg/ml + InjectionAminophylline 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionAminophylline 1 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + InjectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionBretylium tosilate 1 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + InjectionCalcium gluconate 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionCalcium gluconate 2 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + InjectionDigoxin 1 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionDigoxin 1 µg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + InjectionDopamine hydrochloride 0.8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionDopamine hydrochloride 0.8 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionInsulin 1 UI/ml + Ringer’s lactate solution
Incompatible 2 mg/ml + InjectionPhenytoin sodium 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 2 mg/ml + InjectionPhenytoin sodium 1 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + InjectionProcainamide hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + InjectionProcainamide hydrochloride 1 mg/ml + Ringer’s lactate solution
InjectionPhenytoin sodium Antiepileptic
Incompatible 1 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
InjectionProcainamide hydrochloride Anti-arrhythmic
Compatible 1 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution

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