Last update :
18/04/2024
References   References 3766  
Type : Journal
Web link : http://www.pharmactuel.com/index.php/pharmactuel/issue/view/101

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Forrest J.M, Hildgen P.
Title : Compatibilité de l’acétylcystéine injectable lors de son administration en Y avec d’autres médicaments usuels
Reference : Pharmactuel ; 47, 3 : 161-165. 2014

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAciclovir sodium Antiviral
Incompatible 50 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionAminophylline Various
Incompatible 50 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 50 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionAmphotericin B Antifungal
Incompatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionAmpicillin sodium Antibiotic
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionAtropine sulfate Antimuscarinic
Compatible 0.4 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionAzithromycine Antibiotic
Compatible 500 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionBretylium tosilate Anti-arrhythmic
Compatible 50 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCaffeine Respiratory stimulant
Compatible 10 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCalcium chloride Electrolyte
Compatible 78 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCaspofungin acetate Antifungal
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCefazolin sodium Antibiotic
Incompatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCefotaxime sodium Antibiotic
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCefoxitin sodium Antibiotic
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCeftazidime Antibiotic
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCeftriaxone disodium Antibiotic
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCefuroxime sodium Antibiotic
Incompatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionChlorpromazine hydrochloride Anxiolytic
Incompatible 25 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCiclosporin Immunosuppressant
Incompatible 50 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionClindamycin phosphate Antibiotic
Compatible 150 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCloxacillin sodium Antibiotic
Incompatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionCo-trimoxazole Antibiotic
Compatible 16/80 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 4 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionDiazepam Anxiolytic
Compatible 5 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionDigoxin Cardiotonic
Compatible 50 µg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionDobutamine hydrochloride Cardiotonic
Incompatible 12.5 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionDroperidol Neuroleptic
Compatible 2.5 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionEnalaprilate Antihypertensive
Compatible 1.25 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionEpinephrine hydrochloride Sympathomimetic
Incompatible 1000 µg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionErythromycin lactobionate Antibiotic
Incompatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionFentanyl citrate Analgesic
Incompatible 50 µg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionFurosemide Diuretic
Compatible 10 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionGentamicin sulfate Antibiotic
Compatible 40 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionHydralazine hydrochloride Antihypertensive
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionInsulin Glucose-lowering
Incompatible 100 UI/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionLidocaine hydrochloride Local anesthetic
Compatible 1 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionMannitol Various
Compatible 250 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionMetronidazole Antiparasitic
Incompatible 5 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionMidazolam hydrochloride Anxiolytic
Compatible 5 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionN-acetylcysteine Antidote
Incompatible 200 mg/ml + InjectionAciclovir sodium 50 mg/ml + None
Compatible 200 mg/ml + InjectionAmikacin sulfate 250 mg/ml + None
Incompatible 200 mg/ml + InjectionAminophylline 50 mg/ml + None
Compatible 200 mg/ml + InjectionAmiodarone hydrochloride 50 mg/ml + None
Incompatible 200 mg/ml + InjectionAmphotericin B + None
Compatible 200 mg/ml + InjectionAmpicillin sodium + None
Compatible 200 mg/ml + InjectionAtropine sulfate 0.4 mg/ml + None
Compatible 200 mg/ml + InjectionAzithromycine 500 mg/ml + None
Compatible 200 mg/ml + InjectionBretylium tosilate 50 mg/ml + None
Compatible 200 mg/ml + InjectionCaffeine 10 mg/ml + None
Compatible 200 mg/ml + InjectionCalcium chloride 78 mg/ml + None
Compatible 200 mg/ml + InjectionCalcium gluconate 100 mg/ml + None
Compatible 200 mg/ml + InjectionCaspofungin acetate + None
Incompatible 200 mg/ml + InjectionCefazolin sodium + None
Compatible 200 mg/ml + InjectionCefotaxime sodium + None
Compatible 200 mg/ml + InjectionCefoxitin sodium + None
Compatible 200 mg/ml + InjectionCeftazidime + None
Compatible 200 mg/ml + InjectionCeftriaxone disodium + None
Incompatible 200 mg/ml + InjectionCefuroxime sodium + None
Incompatible 200 mg/ml + InjectionChlorpromazine hydrochloride 25 mg/ml + None
Incompatible 200 mg/ml + InjectionCiclosporin 50 mg/ml + None
Compatible 200 mg/ml + InjectionCiprofloxacin lactate 2 mg/ml + None
Compatible 200 mg/ml + InjectionClindamycin phosphate 150 mg/ml + None
Incompatible 200 mg/ml + InjectionCloxacillin sodium + None
Compatible 200 mg/ml + InjectionCo-trimoxazole 16/80 mg/ml + None
Incompatible 200 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + None
Compatible 200 mg/ml + InjectionDiazepam 5 mg/ml + None
Compatible 200 mg/ml + InjectionDigoxin 50 µg/ml + None
Compatible 200 mg/ml + InjectionDiphenhydramine hydrochloride 50 mg/ml + None
Incompatible 200 mg/ml + InjectionDobutamine hydrochloride 12.5 mg/ml + None
Compatible 200 mg/ml + InjectionDopamine hydrochloride 3.2 mg/ml + None
Compatible 200 mg/ml + InjectionDroperidol 2.5 mg/ml + None
Compatible 200 mg/ml + InjectionEnalaprilate 1.25 mg/ml + None
Incompatible 200 mg/ml + InjectionEpinephrine hydrochloride 1000 µg/ml + None
Incompatible 200 mg/ml + InjectionErythromycin lactobionate + None
Incompatible 200 mg/ml + InjectionFentanyl citrate 50 µg/ml + None
Compatible 200 mg/ml + InjectionFluconazole 2 mg/ml + None
Compatible 200 mg/ml + InjectionFurosemide 10 mg/ml + None
Compatible 200 mg/ml + InjectionGentamicin sulfate 40 mg/ml + None
Compatible 200 mg/ml + InjectionHeparin sodium 1000 UI/ml + None
Compatible 200 mg/ml + InjectionHydralazine hydrochloride + None
Compatible 200 mg/ml + InjectionHydrocortisone sodium succinate + None
Incompatible 200 mg/ml + InjectionInsulin 100 UI/ml + None
Compatible 200 mg/ml + InjectionLabetalol hydrochloride 5 mg/ml + None
Compatible 200 mg/ml + InjectionLidocaine hydrochloride 1 mg/ml + None
Compatible 200 mg/ml + InjectionMannitol 250 mg/ml + None
Incompatible 200 mg/ml + InjectionMetronidazole 5 mg/ml + None
Compatible 200 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
Compatible 200 mg/ml + InjectionMilrinone lactate 1 mg/ml + None
Compatible 200 mg/ml + InjectionNitroglycerin 5 mg/ml + None
Compatible 200 mg/ml + InjectionNorepinephrine bitartrate 1 mg/ml + None
Compatible 200 mg/ml + InjectionPiperacillin sodium + None
Compatible 200 mg/ml + InjectionPiperacillin sodium / tazobactam + None
Compatible 200 mg/ml + InjectionPotassium chloride 200 mEq/l + None
Compatible 200 mg/ml + InjectionPropranolol hydrochloride 1 mg/ml + None
Compatible 200 mg/ml + InjectionRanitidine hydrochloride 25 mg/ml + None
Compatible 200 mg/ml + InjectionRocuronium bromide 10 mg/ml + None
Compatible 200 mg/ml + InjectionSodium bicarbonate 84 mg/ml + None
Compatible 200 mg/ml + InjectionTicarcillin / clavulanic acid 31 mg/ml + None
Compatible 200 mg/ml + InjectionVerapamil hydrochloride 2.5 mg/ml + None
InjectionNitroglycerin Vasodilator
Compatible 5 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionPiperacillin sodium Antibiotic
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible + InjectionN-acetylcysteine 200 mg/ml + None
InjectionPotassium chloride Electrolyte
Compatible 200 mEq/l + InjectionN-acetylcysteine 200 mg/ml + None
InjectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 25 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionRocuronium bromide Curarimimetic
Compatible 10 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
InjectionVerapamil hydrochloride Anti-arrhythmic
Compatible 2.5 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None

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