Dernière mise à jour :
18/04/2024
Anticancéreux   Etoposide  
Injectable
Solution buvable
Stabilité des solutions Stabilité en mélange Facteur influençant la stabilité Compatibilités Voie d’administration Bibliographie Pdf
   Structure chimique  

Noms commerciaux   Noms commerciaux     

Les noms commerciaux sont donnés à titre indicatif et la composition en excipients peut être différente selon les pays et selon les laboratoires

Eposin Afrique du sud, Belgique, Colombie, Grande Bretagne, Malaisie, Norvège, Suède
Etocris Argentine, Chili, Pérou
Etolon Inde
Etomedac Allemagne, Luxembourg
Etonolver Vénézuela
Etoposide France, Grèce, Pays bas
Etosid Egypte, Inde, Malaisie
Eunades Brésil
Euvaxon Argentine
Exitop Allemagne, Finlande, Suède
Fytosid Egypte, Inde, Malaisie
Lastet Egypte, Emirats Arabes Unis , Hongrie, Iran, Italie, Pologne, Turquie
Onkoposid Allemagne
Riboposid Allemagne
Sedol Pérou
Toposin Pays bas
Tosuben Mexique
Vepesid Afrique du sud, Allemagne, Arabie Saoudite, Australie, Autriche, Belgique, Canada, Colombie, Croatie, Danemark, Egypte, Espagne, Etats Unis d’Amérique, Finlande, Grèce, Hongrie, Irlande, Italie, Luxembourg, Pays bas, Pologne, Slovénie, Suisse, Turquie
Vepeside Maroc, Tunisie
Bibliographie   Injectable   Bibliographie : Etoposide  
Type Source
3 Revue Trissel LA, Martinez JF.
Compatibility of amifostine with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 2208-2212.
57 Revue Mayron D, Gennaro AR.
Stability and compatibility of granisetron hydrochloride in IV solutions and oral liquids and during simulated Y-site injection with selected drugs.
Am J Health-Syst Pharm 1996 ; 53: 294-304.
81 Revue Trissel LA, Martinez JF.
Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 672-678.
84 Revue Trissel LA, Martinez JF.
Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 495-499.
85 Revue Trissel LA, Bready BB.
Turbidimetric assessment of the compatibility of taxol with selected other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 1716-1719.
91 Revue Lober CA, Dollard PA.
Visual compatibility of gallium nitrate with selected drugs during Y-site injection.
Am J Hosp Pharm 1993 ; 50: 1208-1210.
99 Revue Trissel LA, Martinez JF.
Compatibility of aztreonam with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 1086-1090.
140 Revue Pearson SD, Trissel LA.
Leaching of diethylhexyl phthalate from polyvinyl chloride containers by selected drugs and formulation components.
Am J Hosp Pharm 1993 ; 50: 1405-1409.
150 Revue Aujoulat P, Coze C, Braguer D, Raybaud C.
Physicochemical compatibility of methotrexate with co-administered drugs during cancer chemotherapy regimens.
J Pharm Clin 1993 ; 12: 31-35.
152 Revue Chevrier R, Sautou V, Pinon V, Demecop F, Chopineau J.
Stability and compatibility of a mixture of the anti-cancer drugs etoposide, cytarabine and daunorubicine for infusion.
Pharm Acta Helv 1995 ; 70: 141-148.
161 Revue Barthes DM, Rochard EB, Pouliquen IJ, Rabouan SM, Courtois PY.
Stability and compatibility of etoposide in 0.9% sodium chloride injection in three containers.
Am J Hosp Pharm 1994 ; 51: 2706-2709.
169 Revue Trissel LA, Martinez JF.
Physical compatibility of melphalan with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1993 ; 50: 2359-2363.
182 Revue Trissel LA, Gilbert DL, Martinez JF.
Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 56-60.
184 Revue Stewart JT, Warren FW, King DT, Fox JL.
Stability of ondansetron hydrochloride and five antineoplasic medications.
Am J Health-Syst Pharm 1996 ; 53: 1297-1300.
244 Revue Trissel LA, Martinez JF.
Compatibility of filgrastim with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1907-1913.
249 Revue Trissel LA, Martinez JF.
Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1996 ; 53: 1041-1045.
251 Revue Trissel LA, Gilbert DL, Martinez JF.
Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 2708-2713.
307 Revue Trissel LA, Martinez JF.
Compatibility of allopurinol sodium with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1792-1799.
331 Revue Marquardt ED.
Visual compatibility of hydroxyzine hydrochloride with various antineoplasic agents.
Am J Hosp Pharm 1988 ; 45: 2127.
334 Revue Trissel LA, Tramonte SM, Grilley BJ.
Visual compatibility of ondansetron hydrochloride with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 988-992.
335 Revue Trissel LA, Bready BB, Kwan JW, Santiago NM.
Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 402-406.
417 Revue Stewart CF, Hampton EM.
Stability of cisplatin and etoposide in intravenous admixtures.
Am J Hosp Pharm 1989 ; 46: 1400-1404.
482 Revue Beijnen JH, Beijnen-Bandhoe U, Dubbelman AC, Van Gijn R, Underberg WJM.
Chemical and physical stability of etoposide and teniposide in commonly used infusion fluids.
J Parenter Sci Technol 1991 ; 45: 108-112.
491 Revue Turowski RC, Durthaler JM.
Visual compatibility of idarubicin hydrochloride with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2181-2184.
492 Revue Trissel LA, Parks NPT, Santiago NM.
Visual compatibility of fludarabine phosphate with antineoplastic drugs, anti-infectives, and other selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2186-2189.
504 Revue Hamon M, Plas-Remoissenet D, Kubab-Alajati S.
Etude de la stabilité dans des solutions diluées destinées à la perfusion de deux antimitotiques dérivés de la podophyllotoxine : l’étoposide (VP 16), le téniposide (VM 26).
Sci Tech Pharm 1987 ; 3: 33-40.
643 Revue Seargeant LE, Kobrinsky NL, Sus CJ, Nazeravich DR.
In vitro stability and compatibility of daunorubicin, cytarabine, and etoposide.
Cancer Treat Rep 1987 ; 71: 1189-1192.
905 Revue Trissel LA, Martinez JF.
Screening teniposide for Y-site physical incompatibilities.
Hosp Pharm 1994 ; 29: 1010-1017.
1026 Revue Mayron D, Gennaro AR.
Stability and compatibility of topotecan hydrochloride with selected drugs.
Am J Health-Syst Pharm 1999 ; 56: 875-881.
1033 Revue Wolfe JL, Thoma LA, Du C, Goldspiel BR, Gallelli JF, Grimes GJ, Potti GK.
Compatibility and stability of vincristine sulfate, doxorubicin hydrochloride, and etoposide in 0.9% sodium chloride injection.
Am J Health-Syst Pharm 1999 ; 56: 985-989.
1423 Revue Trissel LA, Martinez JF, Gilbert DL.
Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 514-518.
1496 Revue Trissel LA, Martinez JF, Gilbert DL.
Screening cladribine for Y-site physical compatibility with selected drugs.
Hosp Pharm 1996 ; 31: 1425-1428.
1520 Laboratoire Etude de stabilité des médicaments en Ecoflac®
B Braun 2001
1613 Revue Lepage R, Walker SE, Godin J.
Stability and compatibility of etoposide in normal saline.
Can J Hosp Pharm 2000 ; 53: 338-345.
1722 Revue Gras C, Sautou-Miranda V, Bagel-Boithias S, Brigas F, Chopineau J.
Compatibility of etoposide solution with polyvinyl chloride and low density polyethylene containers and its stability in different storage conditions.
EJHP 2002 ; 2: 33-40.
1730 Revue Björkman S, Roth B.
Chemical compatibility of mitoxantrone and etoposide (VP-16).
Act Pharm Nord 1991 ; 3: 251.
1819 Revue Demoré B, Vigneron J, Perrin A, Hoffman MA, Hoffman M.
Leaching of diethyl hexyl phtalate from polyvinyl chloride bags into intravenous etoposide solution.
J Clin Pharm Ther 2002 ; 27: 139-142.
1895 Revue Bourdeaux D, Sautou-Miranda V, Bagel-Boithias S, Boyer A, Chopineau J.
Analysis by liquid chromatography and infrared spectrometry of di(2-ethylhexyl)phtalate released by multilayer infusion tubing.
J Pharm Biomed Anal 2004 ; 35: 57-64.
1984 Revue Bagel-Boithias S, Sautou-Miranda V, Bourdeaux D, Tramier V, Boyer A, Chopineau J.
Leaching of diethylhexyl phtalate from multilayer tubing into etoposide infusion solutions.
Am J Health-Syst Pharm 2005 ; 62: 182-188.
2108 Revue Trusley C, Kupiec TC, Trissel LA.
Compatibility of micafungin injection with other drugs during simulated Y-site co-administration.
Int J Pharm Compound 2006 ; 10: 230-232.
2167 Revue Joel SP, Clark PI, Slevin ML.
Stability of the iv and oral formulations of etoposide in solution.
Cancer Chemother Pharmacol 1995 ; 37, 1: 117-124.
3574 Laboratoire Ondansetron - Résumé des caractéristiques du produit
Accord Healthcare France SAS 2013
3670 Revue Sewell G, Massimini M.
Studies on the stability and compatibility of cytotoxic drug infusion with the Tevadaptor system.
EJOP 2014 ; 8, 3: 26-30.
4024 Poster Sadou Yaye H, Rieber Z, HassaniI L, Hoffmann-Martinot C, Babiard M, Aouti H, Bellanger A, Tilleul P.
Pénurie mondiale d'Etopophos et conséquences pratiques : Intérêt des études de stabilité dans le choix d'un générique.
SFPO Congress 2017 - Nantes 2017
4125 Revue D'Huart E, Vigneron J, Lider P, Demoré B.
Physicochemical stability of etoposide diluted at range concentrations between 0.38 and 1.75 mg/mL in polyolefin bags.
EJHP 2020 ; 27, 1: 43-48.
4304 Revue Klasen K, Kessari R, Mercier L, Valade C, Grill J, Desmaris R, Paci A.
Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices.
Drugs R D 2014 ; 14:13?23.
4352 Revue Li J, Yao C, Xu Y, Ping P, Yin H, Sun Y.
In vitro compatibility and stability of admixtures containing etoposide, epirubicin hydrochloride and vindesine sulphate in a single infusion bag.
J Clin Pharm Ther 2019 ; 44: 875-882.
4369 Revue Sadou Yayé H, Hassani L, Secrétan PH, Babiard M, Aouati H, Bellanger A, Tilleul P, Yagoubi N, Do B, Rietveld I.
Physical and chemical stability of a generic etoposide formulation as an alternative to etoposide phosphate
J Pharm Biomed Anal 2020 ;178:112896

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