Last update :
21/10/2020
References   References 2167  
Type : Journal

Research teams : London - Saint Bartelemew Hospital, Department of Medical Oncology
Authors : Joel SP, Clark PI, Slevin ML.
Title : Stability of the iv and oral formulations of etoposide in solution.
Reference : Cancer Chemother Pharmacol ; 37, 1: 117-124. 1995

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products not observed in real conditions

List of drugs
InjectionEtoposide Anticancer drug
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.25 mg/ml 8-12°C Not specified
21 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0.4 mg/ml 20-23°C Light
7 Day

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