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Anticancer drug   Etoposide  
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Incompatibilities Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Eposin Belgium, Colombia, Great Britain, Malaysia, Norway, Republic of South Africa, Sweden
Etocris Argentina, Chile, Peru
Etolon India
Etomedac Germany, Luxembourg
Etonolver Venezuela
Etoposide France, Greece, Netherlands
Etosid Egypt, India, Malaysia
Eunades Brazil
Exitop Finland, Germany, Sweden
Fytosid Egypt, India, Malaysia
Lastet Egypt, Hungary, Iran, Italy, Poland, Turkey, United Arab Emirates
Onkoposid Germany
Riboposid Germany
Sedol Peru
Toposin Netherlands
Tosuben Mexico
Vepesid Australia, Austria, Belgium, Canada, Colombia, Croatia, Denmark, Egypt, Finland, Germany, Greece, Hungary, Ireland, Italy, Luxembourg, Netherlands, Poland, Republic of South Africa, Saudi Arabia, Slovenia, Spain, Switzerland, Turkey, United States of America
Vepeside Morocco, Tunisia
References   Injection   References : Etoposide  
Type Publication
57 Journal Mayron D, Gennaro AR.
Stability and compatibility of granisetron hydrochloride in IV solutions and oral liquids and during simulated Y-site injection with selected drugs.
Am J Health-Syst Pharm 1996 ; 53: 294-304.
91 Journal Lober CA, Dollard PA.
Visual compatibility of gallium nitrate with selected drugs during Y-site injection.
Am J Hosp Pharm 1993 ; 50: 1208-1210.
140 Journal Pearson SD, Trissel LA.
Leaching of diethylhexyl phthalate from polyvinyl chloride containers by selected drugs and formulation components.
Am J Hosp Pharm 1993 ; 50: 1405-1409.
152 Journal Chevrier R, Sautou V, Pinon V, Demecop F, Chopineau J.
Stability and compatibility of a mixture of the anti-cancer drugs etoposide, cytarabine and daunorubicine for infusion.
Pharm Acta Helv 1995 ; 70: 141-148.
161 Journal Barthes DM, Rochard EB, Pouliquen IJ, Rabouan SM, Courtois PY.
Stability and compatibility of etoposide in 0.9% sodium chloride injection in three containers.
Am J Hosp Pharm 1994 ; 51: 2706-2709.
184 Journal Stewart JT, Warren FW, King DT, Fox JL.
Stability of ondansetron hydrochloride and five antineoplasic medications.
Am J Health-Syst Pharm 1996 ; 53: 1297-1300.
244 Journal Trissel LA, Martinez JF.
Compatibility of filgrastim with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1907-1913.
417 Journal Stewart CF, Hampton EM.
Stability of cisplatin and etoposide in intravenous admixtures.
Am J Hosp Pharm 1989 ; 46: 1400-1404.
482 Journal Beijnen JH, Beijnen-Bandhoe U, Dubbelman AC, Van Gijn R, Underberg WJM.
Chemical and physical stability of etoposide and teniposide in commonly used infusion fluids.
J Parenter Sci Technol 1991 ; 45: 108-112.
491 Journal Turowski RC, Durthaler JM.
Visual compatibility of idarubicin hydrochloride with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2181-2184.
504 Journal Hamon M, Plas-Remoissenet D, Kubab-Alajati S.
Etude de la stabilité dans des solutions diluées destinées à la perfusion de deux antimitotiques dérivés de la podophyllotoxine : l’étoposide (VP 16), le téniposide (VM 26).
Sci Tech Pharm 1987 ; 3: 33-40.
643 Journal Seargeant LE, Kobrinsky NL, Sus CJ, Nazeravich DR.
In vitro stability and compatibility of daunorubicin, cytarabine, and etoposide.
Cancer Treat Rep 1987 ; 71: 1189-1192.
1026 Journal Mayron D, Gennaro AR.
Stability and compatibility of topotecan hydrochloride with selected drugs.
Am J Health-Syst Pharm 1999 ; 56: 875-881.
1033 Journal Wolfe JL, Thoma LA, Du C, Goldspiel BR, Gallelli JF, Grimes GJ, Potti GK.
Compatibility and stability of vincristine sulfate, doxorubicin hydrochloride, and etoposide in 0.9% sodium chloride injection.
Am J Health-Syst Pharm 1999 ; 56: 985-989.
1520 Manufacturer Etude de stabilité des médicaments en Ecoflac®
B Braun 2001
1613 Journal Lepage R, Walker SE, Godin J.
Stability and compatibility of etoposide in normal saline.
Can J Hosp Pharm 2000 ; 53: 338-345.
1722 Journal Gras C, Sautou-Miranda V, Bagel-Boithias S, Brigas F, Chopineau J.
Compatibility of etoposide solution with polyvinyl chloride and low density polyethylene containers and its stability in different storage conditions.
EJHP 2002 ; 2: 33-40.
1730 Journal Bj?rkman S, Roth B.
Chemical compatibility of mitoxantrone and etoposide (VP-16).
Act Pharm Nord 1991 ; 3: 251.
1819 Journal Demoré B, Vigneron J, Perrin A, Hoffman MA, Hoffman M.
Leaching of diethyl hexyl phtalate from polyvinyl chloride bags into intravenous etoposide solution.
J Clin Pharm Ther 2002 ; 27: 139-142.
1895 Journal Bourdeaux D, Sautou-Miranda V, Bagel-Boithias S, Boyer A, Chopineau J.
Analysis by liquid chromatography and infrared spectrometry of di(2-ethylhexyl)phtalate released by multilayer infusion tubing.
J Pharm Biomed Anal 2004 ; 35: 57-64.
1984 Journal Bagel-Boithias S, Sautou-Miranda V, Bourdeaux D, Tramier V, Boyer A, Chopineau J.
Leaching of diethylhexyl phtalate from multilayer tubing into etoposide infusion solutions.
Am J Health-Syst Pharm 2005 ; 62: 182-188.
2167 Journal Joel SP, Clark PI, Slevin ML.
Stability of the iv and oral formulations of etoposide in solution.
Cancer Chemother Pharmacol 1995 ; 37, 1: 117-124.
3670 Journal Sewell G, Massimini M.
Studies on the stability and compatibility of cytotoxic drug infusion with the Tevadaptor system.
EJOP 2014 ; 8, 3: 26-30.
4024 Poster Sadou Yaye H, Rieber Z, HassaniI L, Hoffmann-Martinot C, Babiard M, Aouti H, Bellanger A, Tilleul P.
Pénurie mondiale d'Etopophos et conséquences pratiques : Intérêt des études de stabilité dans le choix d'un générique.
SFPO Congress 2017 - Nantes 2017
4125 Journal D'Huart E, Vigneron J, Lider P, Demor? B.
Physicochemical stability of etoposide diluted at range concentrations between 0.38 and 1.75 mg/mL in polyolefin bags.
EJHP 2018
4304 Journal Klasen K, Kessari R, Mercier L, Valade C, Grill J, Desmaris R, Paci A.
Stability of Etoposide Solutions in Disposable Infusion Devices for Day Hospital Cancer Practices.
Drugs R D 2014 ; 14:13?23.
4352 Journal Li J, Yao C, Xu Y, Ping P, Yin H, Sun Y.
In vitro compatibility and stability of admixtures containing etoposide, epirubicin hydrochloride and vindesine sulphate in a single infusion bag.
J Clin Pharm Ther 2019 ; 44: 875-882.
4369 Journal Sadou Yayé H, Hassani L, Secrétan PH, Babiard M, Aouati H, Bellanger A, Tilleul P, Yagoubi N, Do B, Rietveld I.
Physical and chemical stability of a generic etoposide formulation as an alternative to etoposide phosphate
J Pharm Biomed Anal 2020 ;178:112896

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