Last update :
31/05/2020
References   References 4352  
Type : Journal
Web link : https://doi.org/10.1111/jcpt.13007

Research teams : Beijing - The General Hospital of Chinese People's Liberation Army International Convention Center
Authors : Li J, Yao C, Xu Y, Ping P, Yin H, Sun Y.
Title : In vitro compatibility and stability of admixtures containing etoposide, epirubicin hydrochloride and vindesine sulphate in a single infusion bag.
Reference : J Clin Pharm Ther ; 44: 875-882. 2019

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionEpirubicin hydrochloride Anticancer drug
InjectionEtoposide Anticancer drug
InjectionVindesine sulfate Anticancer drug
Stability of mixtures
Polyolefine Sodium chloride 0,9% 25°C Light
Injection Etoposide 0,125 mg/ml
Injection Epirubicin hydrochloride 0,0375 mg/ml
Injection Vindesine sulfate 0,002 mg/ml
24 Hour
Polyolefine Sodium chloride 0,9% 25°C Light
Injection Vindesine sulfate 0,0028 mg/ml
Injection Epirubicin hydrochloride 0,0525 mg/ml
Injection Etoposide 0,175 mg/ml
24 Hour
Polyolefine Sodium chloride 0,9% 25°C Light
Injection Etoposide 0,250 mg/ml
Injection Epirubicin hydrochloride 0,075 mg/ml
Injection Vindesine sulfate 0,004 mg/ml
24 Hour

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