Last update :
27/10/2020
References   References 482  
Type : Journal PC : 0.0006830601092896 

Research teams : Utrecht - Faculty of pharmacy, State university of Utrecht
Authors : Beijnen JH, Beijnen-Bandhoe U, Dubbelman AC, Van Gijn R, Underberg WJM.
Title : Chemical and physical stability of etoposide and teniposide in commonly used infusion fluids.
Reference : J Parenter Sci Technol ; 45: 108-112. 1991

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified

List of drugs
InjectionEtoposide Anticancer drug
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,4 mg/ml 20°C-22°C Light
4 Day
Stability in solutions Glass Ringer’s lactate solution 0,4 mg/ml 20°C-22°C Light
4 Day
InjectionTeniposide Anticancer drug
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,4 mg/ml 20°C-22°C Light
4 Day
Stability in solutions Glass Ringer’s lactate solution 0,4 mg/ml 20°C-22°C Light
4 Day

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