Last update :
21/10/2020
References   References 161  
Type : Journal

Research teams : Poitiers - Université de Poitiers, Faculté de Médecine et Pharmacie
Authors : Barthes DM, Rochard EB, Pouliquen IJ, Rabouan SM, Courtois PY.
Title : Stability and compatibility of etoposide in 0.9% sodium chloride injection in three containers.
Reference : Am J Hosp Pharm ; 51: 2706-2709. 1994

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Search of DEHP 
Comments : 
No comments for the degradation products

List of drugs
InjectionEtoposide Anticancer drug
Factors which affect stability Container Polyvinyl chloride Induces Leaching
Stability in solutions Glass Sodium chloride 0,9% 0,4 mg/ml 24°C Not specified
24 Hour
Stability in solutions Glass Sodium chloride 0,9% 0,4 mg/ml 4°C Not specified
24 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 0,4 mg/ml 24°C Not specified
24 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 0,4 mg/ml 4°C Not specified
24 Hour

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