Last update :
21/10/2020
References   References 152  
Type : Journal

Research teams : Clermont-Ferrand - University Hospital Gabriel Monpied, Department of Pharmacy
Authors : Chevrier R, Sautou V, Pinon V, Demecop F, Chopineau J.
Title : Stability and compatibility of a mixture of the anti-cancer drugs etoposide, cytarabine and daunorubicine for infusion.
Reference : Pharm Acta Helv ; 70: 141-148. 1995

Level of Evidence : 
Joker
Level of Evidence : 
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No comments for the degradation products

List of drugs
InjectionCytarabine Anticancer drug
Stability in solutions Polypropylene Glucose 5% 0,157 mg/ml 25°C With or without light
48 Hour
Stability in solutions Polypropylene Glucose 5% 0,157 mg/ml 4°C With or without light
48 Hour
InjectionDaunorubicin hydrochloride Anticancer drug
Stability in solutions Polypropylene Glucose 5% 0,0157 mg/ml 25°C With or without light
48 Hour
Stability in solutions Polypropylene Glucose 5% 0,0157 mg/ml 4°C With or without light
48 Hour
InjectionEtoposide Anticancer drug
Stability in solutions Polypropylene Glucose 5% 0,157 mg/ml 25°C With or without light
48 Hour
Stability in solutions Polypropylene Glucose 5% 0,157 mg/ml 4°C With or without light
48 Hour
Stability of mixtures
Polypropylene Glucose 5% 25°C With or without light
Injection Etoposide 0,157 mg/ml
Injection Cytarabine 0,157 mg/ml
Injection Daunorubicin hydrochloride 0,0157 mg/ml
48 Hour
Polypropylene Glucose 5% 4°C Protect from light
Injection Etoposide 0,157 mg/ml
Injection Cytarabine 0,157 mg/ml
Injection Daunorubicin hydrochloride 0,0157 mg/ml
48 Hour

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