Last update :
21/10/2020
References   References 4125  
Type : Journal
Web link : https://ejhp.bmj.com/content/early/2018/07/07/ejhpharm-2018-001571
Icone.pdf
389Ko

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : D'Huart E, Vigneron J, Lider P, Demor? B.
Title : Physicochemical stability of etoposide diluted at range concentrations between 0.38 and 1.75 mg/mL in polyolefin bags.
Reference : EJHP 2018

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionEtoposide Anticancer drug
Stability in solutions Polyolefine Glucose 5% 0,38 mg/ml 25°C Protect from light
61 Day
Stability in solutions Polyolefine Glucose 5% 0,74 mg/ml 25°C Protect from light
61 Day
Stability in solutions Polyolefine Glucose 5% 1,26 mg/ml 25°C Protect from light
61 Day
Stability in solutions Polyolefine Glucose 5% 1,75 mg/ml 25°C Protect from light
28 Day

  Mentions Légales