Last update :
19/10/2020
References   References 1722  
Type : Journal

Research teams : Clermont-Ferrand - University Hospital Gabriel Monpied, Department of Pharmacy
Authors : Gras C, Sautou-Miranda V, Bagel-Boithias S, Brigas F, Chopineau J.
Title : Compatibility of etoposide solution with polyvinyl chloride and low density polyethylene containers and its stability in different storage conditions.
Reference : EJHP ; 2: 33-40. 2002

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Search of DEHP 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionEtoposide Anticancer drug
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,05 & 0,2 mg/ml 20-25°C With or without light
7 Day
Stability in solutions Polyethylene NaCl 0,9% or Glucose 5% 0,05 & 0,2 mg/ml 4°C Protect from light
7 Day

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