Last update :
04/08/2021
References   References 4491  
Type : Journal
Web link : https://doi.org/10.1007/s00431-020-03854-7

Research teams : Barakaldo - Biocruces Bizkaia Health Research Institute
Authors : De Basagoiti A, Katsumiti A, Abascal S, Bustinza A, López-Giménez L.R, Pilar P, De Miguel M, Campino A.
Title : Physical compatibility of alprostadil with selected drugs commonly used in the neonatal intensive care units.
Reference : Eur J Pedia 2020

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAlprostadil Vasodilator
Compatible 20 µg/ml + InjectionAmiodarone hydrochloride 6 mg/ml + Glucose 5%
Compatible 20 µg/ml + InjectionCalcium gluconate 0,04 mg/ml + Glucose 10%
Incompatible 20 µg/ml + InjectionCisatracurium besylate 1,2 mg/ml + Glucose 5%
Compatible 20 µg/ml + InjectionDexmedetomidine 4 µg/ml + Glucose 5%
Compatible 20 µg/ml + InjectionDobutamine hydrochloride 10 mg/ml + Glucose 5%
Compatible 20 µg/ml + InjectionDopamine hydrochloride 10 mg/ml + Glucose 5%
Compatible 20 µg/ml + InjectionEpinephrine hydrochloride 0,2 µg/ml + Glucose 5%
Compatible 20 µg/ml + InjectionFentanyl citrate 40 µg/ml + Sodium chloride 0,9%
Compatible 20 µg/ml + InjectionFlecainide acetate 2 mg/ml + Glucose 5%
Compatible 20 µg/ml + InjectionFurosemide 5 mg/ml + Sodium chloride 0,9%
Compatible 20 µg/ml + InjectionHeparin sodium 1 UI/ml + Sodium chloride 0,9%
Incompatible 20 µg/ml + InjectionInsulin 1 UI/ml + Glucose 5%
Compatible 20 µg/ml + InjectionKetamine hydrochloride 5 mg/ml + Glucose 5%
Compatible 20 µg/ml + InjectionMidazolam hydrochloride 2,5 mg/ml + Glucose 5%
Compatible 20 µg/ml + InjectionMilrinone lactate 0,5 mg/ml + Glucose 5%
Incompatible 20 µg/ml + InjectionNorepinephrine bitartrate 0,5 mg/ml + Glucose 5%
InjectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 6 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionCalcium gluconate Electrolyte
Compatible 0,04 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 10%
InjectionCisatracurium besylate Curarimimetic
Incompatible 1,2 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionDexmedetomidine Sympathomimetic
Compatible 4 µg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 10 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 10 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 0,2 µg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionFentanyl citrate Analgesic
Compatible 40 µg/ml + InjectionAlprostadil 20 µg/ml + Sodium chloride 0,9%
InjectionFlecainide acetate Anti-arrhythmic
Compatible 2 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionFurosemide Diuretic
Compatible 5 mg/ml + InjectionAlprostadil 20 µg/ml + Sodium chloride 0,9%
InjectionHeparin sodium Anticoagulant
Compatible 1 UI/ml + InjectionAlprostadil 20 µg/ml + Sodium chloride 0,9%
InjectionInsulin Glucose-lowering
Incompatible 1 UI/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionKetamine hydrochloride General anesthetic
Compatible 5 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionMidazolam hydrochloride Anxiolytic
Compatible 2,5 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionMilrinone lactate Cardiotonic
Compatible 0,5 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%
InjectionNorepinephrine bitartrate Sympathomimetic
Incompatible 0,5 mg/ml + InjectionAlprostadil 20 µg/ml + Glucose 5%

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