Last update :
22/01/2021
General anesthetic   Ketamine hydrochloride  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Incompatibilities Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Aescoket Italy
Anesket Colombia, Mexico
Calypsol Hungary, Malaysia, Poland, Romania, Thailand
Inducmina Argentina, Peru
Kanox Malaysia
Keiram Egypt, Venezuela
Keta Germany, India
Keta Hameln Peru
Ketafast India
Ketajet India
Ketalar Australia, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Finland, Great Britain, Ireland, Luxembourg, Netherlands, New Zealand, Norway, Portugal, Sweden, Turkey, United Arab Emirates, United States of America
Ketalin Mexico
Ketamar Egypt
Ketamax India, Venezuela
Ketamin Germany
Ketamina Argentina, Chile, Colombia, Peru, Venezuela
Ketamine Canada, Egypt, France, Ireland, Italy, Malaysia, New Zealand, Romania, Tunisia, United States of America
Ketanest Poland
Ketanir Colombia, Ecuador, Peru
Ketashort Colombia
Ketava Malaysia
Ketmin India
Ketolar Spain
Ketsia India
Kmin India
Tekam Saudi Arabia, United Arab Emirates
References   Injection   References : Ketamine hydrochloride  
Type Publication
660 Journal Michaels MR, Stauffer GL, Haas DP.
Propofol compatibility with other intravenous drug products - Two new methods of evaluating IV emulsion compatibility.
Ann Pharmacotherapy 1996 ; 30: 228-232.
1714 Journal Gupta VD.
Stability of ketamine hydrochloride injection after reconstitution in water for injection and storage in 1-ml tuberculin polypropylene syringes for pediatric use.
Int J Pharm Compound 2002 ; 6: 316-317.
1864 Journal Lau MH, Hackman C, Morgan DJ.
Compatibility of ketamine and morphin injections.
Pain 1998 ; 75: 389-390.
1993 Journal Lee DKT, Wang DP, Harsono R, Wong CY.
Compatibility of fentanyl citrate, ketamine hydrochloride, and droperidol in 0.9% sodium chloride injection stored in polyvinyl chloride bags.
Am J Health-Syst Pharm 2005 ; 62: 1190-1192.
2022 Journal Watson DG, Lin M, Morton A, Cable CG, McArthur DA.
Compatibility and stability of dexamethasone sodium phosphate and ketamine hydrochloride subcutaneous infusions in polypropylene syringes.
J Pain Symptom Manage 2005 ; 30: 80-86.
2109 Journal Pelletier E, Forest JM, Hildgen P.
Compatibilité de la kétamine injectable lors de l’administration en dérivé avec d’autres médicaments usuels.
Pharmactuel 2006 ; 39: 71-75.
2287 Journal Stucki MC, Leury-Souverain S, Sautter AM, Sadeghipour F, Bonnabry P.
Development of ready-to-use ketamine hydrochloride syringes for safe use in post-operative pain.
EJHP Science 2008 ; 14, 1: 14-18.
2322 Journal Donnelly R.F.
Physical Compatibility and Chemical Stability of Ketamine–Morphine Mixtures in Polypropylene Syringes.
Can J Hosp Pharm 2009 ; 62, 1
2329 Journal Donnely R.F, Willman E, Andolfatto G.
Stability of Ketamine-Propofol mixtures for procedural sedation and analgesia in the emergency department.
Can J Hosp Pharm 2008 ; 61, 6: 426-430.
2336 Journal Ensom M.H.H, Decarie D, Leung K, MontgomeryC
Stability of Hydromorphone–Ketamine Solutions in Glass Bottles, Plastic Syringes, and IV Bags for Pediatric Use
Can J Hosp Pharm 2009 ; 62, 2: 112-118.
2350 Journal Roy J.J, Hildgen P.
Stability of morphine-ketamine in 0.9% sodium chloride injection packaged in syringes, plastic bags and MEDICATION CASSETTE Reservoirs.
Int J Pharm Compound 2000 ; 4, 3: 225-228.
3435 Journal Donnelly R.F.
Stability of Diluted Ketamine Packaged in Glass Vials.
Can J Hosp Pharm 2013 ; 66, 3 : 198.
3501 Manufacturer Ketamine hydrochloride (Ketalar®) - Summary of Product Characteristics
Pfizer 2011
3705 Journal Knudsen L, Eisend S, Haake N, Kunze T.
Physicochemical compatibility of commonly used analgesics and sedatives in the intensive care medicine.
EJHP 2014 ;21:161-166
3859 Journal Foy G, Poinsignon V, Mercier L, Laurent S, Paci A.
Microbiological and Physico-Chemical Stability of Ketamine Solution for Patient-Controlled Analgesia Systems.
RRJHCP 2016 ; 1, 3: 31-37.
3874 Journal Huvelle S, Godet M, Hecq J.D, Gillet P, Bihin B, Jamart J, Galanti L.
Long-term stability of ketamine hydrochloride 50 mg/ml injection in 3 ml syringes
Ann Pharm Fr 2016 ; 74: 283-287.
3911 Journal Closset M, Hecq J D, Gonzalez E, Bihin B, Jamart J, L Galanti L.
Does an interaction exist between ketamine hydrochloride and Becton Dickinson syringes?
EJHP 2017 ; 24: 230-234.
3932 Manufacturer Hydroxocobalamine (Cyanokit®) - Résumé des caractéristiques du produit
Serb Laboratoire 2015
4011 Journal Gersonde F, Eisend S, Haake N, Kunze T.
Physicochemical compatibility and emulsion stability of propofol with commonly used analgesics and sedatives in an intensive care unit.
EJHP 2016 2016;0:1-11
4115 Journal Fang B, Wang L, Gu J, Chen F, Shi X.
Physicochemical stability of ternary admixtures of butorphanol, ketamine, and droperidol in polyolefin bags for patient-controlled analgesia use.
Drug Design Dev Ther 2016 ;10:3873-3878
4143 Journal Daouphars M, Hervou?t C.H, Bohn P, Martin D, Rouvet J, Basuyau F, Varin R.
Physicochemical stability of oxycodone-ketamine solutions in polypropylene syringe and polyvinyl chloride bag for patient-controlled analgesia use.
EJHP 2016 ; 25, 4
4303 Journal Anderson C, MacKay M.
Stability of Fentanyl Citrate, Hydromorphone Hydrochloride, Ketamine Hydrochloride, Midazolam, Morphine Sulfate, and Pentobarbital Sodium in Polypropylene Syringes.
Pharmacy 2015 3, 379-385.
4319 Journal Lessard J-J, Caron E, Schérer H, Forest J-M, Leclair G.
Compatibility of Y-site Injection of Meropenem Trihydrate With 101 Other Injectable Drugs.
Hosp Pharm 2019
4350 Journal Beiler B, Barraud D, Vigneron J, Demor? B.
Physicochemical stability of an admixture of lidocaine and ketamine in polypropylene syringe used in opioid-free anaesthesia.
EJHP 2019 ;0:1-5
4389 Journal Côté K, Correal F, Metras M.E, Friciu M, Forest J.M, Leclair G.
Compatibilité physique des médicaments administrés en Y aux soins intensifs, en particulier la dexmédétomidine, le lévosimendan et la kétamine.
Pharmactuel 2019 ;52,4:206-213

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