Last update :
22/01/2021
References   References 3859  
Type : Journal
Web link : http://www.rroij.com/open-access/microbiological-and-physicochemical-stability-of-ketamine-solution-forpatientcontrolled-analgesia-systems.php?aid=64079

Research teams : Villejuif - Institut Gustave Roussy, Department of Pharmacy
Authors : Foy G, Poinsignon V, Mercier L, Laurent S, Paci A.
Title : Microbiological and Physico-Chemical Stability of Ketamine Solution for Patient-Controlled Analgesia Systems.
Reference : RRJHCP ; 1, 3: 31-37. 2016

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality Water loss by evaporation 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionKetamine hydrochloride General anesthetic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 25°C Not specified
28 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 33°C Not specified
7 Day

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