Last update :
28/04/2024
Antibiotic   Doxycycline hyclate  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Doximycin Finland
Doxy New Zealand, United States of America
Doxycyclin Luxembourg
Doxycycline United States of America
Doxycyclinum Poland
Doxyferm Sweden
Doxyhexal Germany, Luxembourg
Doxylin Norway
Doxymycin Finland
Vibramycin Netherlands, United States of America
Vibraveineuse France, Morocco, Switzerland
Vibravenös Austria, Switzerland
Vibravenosa Colombia, Spain
Vibravenous United Arab Emirates
Zadorin Switzerland
Compatibility   Injection   Compatibility : Doxycycline hyclate              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Aciclovir sodium 5 mg/ml
Glucose 5% 336
Immediate precipitation Incompatible
Injection Doxycycline hyclate 1 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Compatible
Injection Doxycycline hyclate 0.25 mg/ml
Injection Amiodarone hydrochloride 4 mg/ml
NaCl 0,9% or Glucose 5% 385
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Unspecified incompatibility Incompatible
Injection Doxycycline hyclate
Injection Calcium gluconate
3644
Immediate precipitation Incompatible
Injection Doxycycline hyclate 1 mg/ml
Injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Compatible
Injection Doxycycline hyclate 1 & 10 mg/ml
Injection Diltiazem hydrochloride 5 mg/ml
Sodium chloride 0,9% 198
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Docetaxel 0.9 mg/ml
Glucose 5% 1754
Unspecified incompatibility Incompatible
Injection Doxycycline hyclate
Injection Erythromycin lactobionate
3674
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Immediate instability of the emulsion Incompatible
Injection Doxycycline hyclate 1 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Doxycycline hyclate 1 mg/ml
Parenteral nutrition (binary mixture) 301
Color change after 1 hour Incompatible
Injection Doxycycline hyclate 1 mg/ml
Injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Granisetron hydrochloride 0.05 mg/ml
Glucose 5% 182
Compatible
Injection Doxycycline hyclate 10 mg/ml
Parenteral nutrition (binary mixture) 999
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Unspecified incompatibility Incompatible
Injection Doxycycline hyclate 1 mg/ml
Injection Heparin sodium 50 UI/ml
None 317
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Hetastarch 60 mg/ml
Specific solvent 1721
Immediate precipitation Incompatible
Injection Doxycycline hyclate 1 mg/ml
Injection Hetastarch 60 mg/ml
Sodium chloride 0,9% 465
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Hetastarch 60 mg/ml
Sodium chloride 0,9% 472
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Hydromorphone hydrochloride 0.2 mg/ml
Glucose 5% 405
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Magnesium sulfate 16.67 >> 100 mg/ml
Glucose 5% 1047
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Doxycycline hyclate 0.2 & 1 mg/ml
Injection Meropenem 1 mg/ml
Sodium chloride 0,9% 266
Color change after 1 hour Incompatible
Injection Doxycycline hyclate 0,2 & 1 mg/ml
Injection Meropenem 20 & 50 mg/ml
Sodium chloride 0,9% 266
Unspecified incompatibility Incompatible
Injection Doxycycline hyclate
Injection Mitomycin
4471
Chemical instability Incompatible
Injection Doxycycline hyclate
Injection Mitomycin
3128
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Morphine sulfate 1 mg/ml
Glucose 5% 405
Unspecified incompatibility Incompatible
Injection Doxycycline hyclate
Injection Morphine sulfate
3531
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Immediate precipitation Incompatible
Injection Doxycycline hyclate 1 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Pethidine hydrochloride 10 mg/ml
Glucose 5% 405
Compatible
Injection Doxycycline hyclate 5 mg/ml
Injection Phloroglucinol 2,5 mg/ml
3791
Immediate turbidity Incompatible
Injection Doxycycline hyclate 1 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Compatible
Injection Doxycycline hyclate 5 mg/ml
Injection Tacrolimus 1000 µg/ml
Sodium chloride 0,9% 479
Immediate turbidity Incompatible
Injection Doxycycline hyclate 1 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Telavancin hydrochloride 7.5 mg/ml
NaCl 0,9% or Glucose 5% 3254
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Theophylline 4 mg/ml
None 317
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Compatible
Injection Doxycycline hyclate 1 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

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