Last update :
26/03/2024
References   References 4433  
Type : Journal
Web link : https://doi.org/10.1016/j.clinthera.2020.01.017

Research teams : Philadelphia - Philadelphia College of Pharmacy and Science
Authors : Ghazi I.M, El Nekidy W.S, Sood A, Dulku A, Patel R, Patel K.
Title : Y-site Administration of Imipenem/Cilastatin/ Relebactam With Common Intravenous Medications
Reference : Clin Ther ; 42, 3: 475-485. 2020

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionBumetanide Diuretic
Compatible 0,25 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCalcium chloride Electrolyte
Compatible 40 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCisatracurium besylate Curarimimetic
Compatible 0,4 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 1 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDexmedetomidine Sympathomimetic
Compatible 4 µg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + Sodium chloride 0,9%
InjectionDigoxin Cardiotonic
Compatible 0,25 µg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDiltiazem hydrochloride Anti-arrhythmic
Compatible 5 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 3,2 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionEnalaprilate Antihypertensive
Compatible 1,25 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 50 µg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionEptifibatide Anticoagulant
Compatible 2 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionEsomeprazole sodium Proton pump inhibitor
Compatible 0,8 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionFamotidine Antihistamine (H2)
Compatible 4 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionFosphenytoin sodium Antiepileptic
Compatible 37,5 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionFurosemide Diuretic
Incompatible 10 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionHaloperidol lactate Neuroleptic
Incompatible 5 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionHuman albumin Various
Compatible 50 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionHydrocortisone sodium succinate Anti-inflammatory
Incompatible 1 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionImipenem-Cilastatin / Relebactam Antibiotic
Compatible 5 mg/ml + InjectionBumetanide 0,25 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionCalcium chloride 40 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionCalcium gluconate 40 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionCisatracurium besylate 0,4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + InjectionDexamethasone sodium phosphate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionDexmedetomidine 4 µg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionDigoxin 0,25 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionDiltiazem hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionDiphenhydramine hydrochloride 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionDobutamine hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionDopamine hydrochloride 3,2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionEnalaprilate 1,25 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionEpinephrine hydrochloride 50 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionEptifibatide 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionEsmolol hydrochloride 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionEsomeprazole sodium 0,8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionFamotidine 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionFentanyl citrate 50 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionFosphenytoin sodium 37,5 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + InjectionFurosemide 10 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + InjectionHaloperidol lactate 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionHeparin sodium 1000 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionHuman albumin 50 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + InjectionHydrocortisone sodium succinate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionInsulin aspart 1 UI/ml + Sodium chloride 0,9%
Incompatible 5 mg/ml + InjectionInsulin glulisine 1 U/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionInsulin lyspro 1 UI/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionKetorolac tromethamine 30 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + InjectionLabetalol hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionLidocaine hydrochloride 10 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMagnesium sulfate 200 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionMesna 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionMethylprednisolone sodium succinate 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionMetoclopramide hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionMetoprolol tartrate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionMidazolam hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionMilrinone lactate 0,2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionNaloxone hydrochloride 0,004 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionNitroglycerin 0,4 mg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionNorepinephrine bitartrate 0,032 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionOndansetron hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionPantoprazole sodium 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionPhenylephrine hydrochloride 0,2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + InjectionPhenytoin sodium 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionPotassium phosphate 0,4 mmol/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + InjectionPropofol 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionRanitidine hydrochloride 2,5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionRocuronium bromide 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionVasopressin 1 UI/ml + NaCl 0,9% or Glucose 5%
InjectionInsulin Glucose-lowering
Compatible 1 UI/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + Sodium chloride 0,9%
InjectionInsulin aspart Glucose-lowering
Compatible 1 UI/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + Sodium chloride 0,9%
InjectionInsulin glulisine Glucose-lowering
Incompatible 1 U/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionInsulin lyspro Glucose-lowering
Compatible 1 UI/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + Sodium chloride 0,9%
InjectionKetorolac tromethamine Anti-inflammatory
Compatible 30 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionLabetalol hydrochloride Beta-blocker
Incompatible 2 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + Glucose 5%
InjectionMagnesium sulfate Electrolyte
Compatible 200 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMesna Cytoprotective
Compatible 20 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 1 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMetoprolol tartrate Anti-arrhythmic
Compatible 1 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMidazolam hydrochloride Anxiolytic
Compatible 1 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMilrinone lactate Cardiotonic
Compatible 0,2 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionNaloxone hydrochloride Antidote
Compatible 0,004 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionNitroglycerin Vasodilator
Compatible 0,4 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + Glucose 5%
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 0,032 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionOndansetron hydrochloride Antiemetic
Compatible 1 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPantoprazole sodium Proton pump inhibitor
Compatible 4 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPhenylephrine hydrochloride Sympathomimetic
Compatible 0,2 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPhenytoin sodium Antiepileptic
Incompatible 5 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPotassium phosphate Electrolyte
Compatible 0,4 mmol/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPropofol General anesthetic
Incompatible 10 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2,5 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionRocuronium bromide Curarimimetic
Compatible 5 mg/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionVasopressin Hormone
Compatible 1 UI/ml + InjectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%

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