Last update :
19/01/2021
References   References 565  
Type : Journal

Research teams : Salt Lake City - University of Utah Health Care, Department of Pharmacy Services
Authors : Marble DA, Bosso JA, Townsend RJ.
Title : Compatibility of clindamycin phosphate with amikacin sulfate at room temperature and with gentamicin sulfate and tobramycin sulfate under frozen conditions.
Reference : Drug Intell Clin Pharm ; 20: 960-963. 1986

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Method not shown but the article refers to a validated method
No visual inspection
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionAmikacin sulfate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 4 mg/ml 25°C Not specified
48 Hour
InjectionClindamycin phosphate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 9 mg/ml 25°C Not specified
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 9 mg/ml -20°C Protect from light
28 Day
InjectionGentamicin sulfate Antibiotic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,2 mg/ml -20°C Protect from light
28 Day
InjectionTobramycin sulfate Antibiotic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,2 mg/ml -20°C Protect from light
28 Day
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% -20°C Protect from light
Injection Clindamycin phosphate 9 mg/ml
Injection Gentamicin sulfate 1,2 mg/ml
28 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Not specified
Injection Clindamycin phosphate 9 mg/ml
Injection Amikacin sulfate 4 mg/ml
48 Hour
Polyvinyl chloride Sodium chloride 0,9% -20°C Protect from light
Injection Clindamycin phosphate 9 mg/ml
Injection Tobramycin sulfate 1,2 mg/ml
28 Day
Polyvinyl chloride Glucose 5% -20°C Protect from light
Injection Clindamycin phosphate 9 mg/ml
Injection Tobramycin sulfate 1,2 mg/ml
14 Day

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