Last update :
10/08/2022
References   References 418  
Type : Journal

Research teams : Salt Lake City - University of Utah Health Care, Department of Pharmacy Services
Authors : Bosso JA, Townsend RJ.
Title : Stability of clindamycin phosphate and ceftizoxime sodium, cefoxitine sodium, cefamandole nafate, or cefazolin sodium in two intravenous solutions.
Reference : Am J Hosp Pharm ; 42: 2211-2214. 1985

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
InjectionCefamandole nafate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Light
48 Hour
Compatible 10 mg/ml + InjectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCefazolin sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Light
48 Hour
Compatible 10 mg/ml + InjectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCefoxitin sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Light
48 Hour
Compatible 20 mg/ml + InjectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCeftizoxime sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Light
48 Hour
Compatible 20 mg/ml + InjectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
InjectionClindamycin phosphate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 9 mg/ml 25°C Light
48 Hour
Compatible 9 mg/ml + InjectionCefamandole nafate 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + InjectionCefazolin sodium 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + InjectionCefoxitin sodium 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + InjectionCeftizoxime sodium 20 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 25°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Cefoxitin sodium 20 mg/ml
48 Hour
Glass NaCl 0,9% or Glucose 5% 25°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Cefamandole nafate 10 mg/ml
48 Hour
Glass NaCl 0,9% or Glucose 5% 25°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Cefazolin sodium 10 mg/ml
48 Hour
Glass Sodium chloride 0,9% 25°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Ceftizoxime sodium 20 mg/ml
24 Hour
Glass Glucose 5% 25°C Light
Injection Clindamycin phosphate 9 mg/ml
Injection Ceftizoxime sodium 20 mg/ml
48 Hour

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