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References   References 418  
Type : Journal
Web link : https://doi.org/10.1093/ajhp/42.10.2211
Research teams : Salt Lake City - University of Utah Health Care, Department of Pharmacy Services
Authors : Bosso JA, Townsend RJ.
Title : Stability of clindamycin phosphate and ceftizoxime sodium, cefoxitine sodium, cefamandole nafate, or cefazolin sodium in two intravenous solutions.
Reference : Am J Hosp Pharm ; 42: 2211-2214. 1985
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
List of drugs
injectionCefamandole nafate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Light
48 Hour
Compatible 10 mg/ml + injectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
injectionCefazolin sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 25°C Light
48 Hour
Compatible 10 mg/ml + injectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
injectionCefoxitin sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Light
48 Hour
Compatible 20 mg/ml + injectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
injectionCeftizoxime sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Light
48 Hour
Compatible 20 mg/ml + injectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
injectionClindamycin phosphate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 9 mg/ml 25°C Light
48 Hour
Compatible 9 mg/ml + injectionCefamandole nafate 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + injectionCefazolin sodium 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + injectionCefoxitin sodium 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + injectionCeftizoxime sodium 20 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Cefoxitin sodium 20 mg/ml
48 Hour
Glass NaCl 0,9% or Glucose 5% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Cefamandole nafate 10 mg/ml
48 Hour
Glass NaCl 0,9% or Glucose 5% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Cefazolin sodium 10 mg/ml
48 Hour
Glass Sodium chloride 0,9% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Ceftizoxime sodium 20 mg/ml
24 Hour
Glass Glucose 5% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Ceftizoxime sodium 20 mg/ml
48 Hour
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