Monographie - Isosorbide dinitrate - Stabilis 4.0

Last update :
18/04/2024

Vasodilator

Isosorbide dinitrate

Injection

Stability in solutions

Stability of mixtures

Factors which affect stability

Compatibility

Route of administration

References

Pdf

Chemical structure

Tradename

Tradename

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Angsobide	Malaysia
Cedocard	Netherlands
Diniket	Italy
Dinit	Finland
Dinitrato de isosorbida	Peru
Ekilbran	Mexico
Hadirax	Mexico
Isobid	Peru
Isoket	Austria, Egypt, Germany, Great Britain, Hungary, Ireland, Luxembourg, Malaysia, Mexico, Peru, Poland, Portugal, Saudi Arabia, Switzerland, United Arab Emirates, Venezuela
Isonit	Ecuador, Peru
Isosorbida dinitrato	Mexico
Isosorbide dinitrate	Great Britain, Ireland
Nitrosid	Finland
Nitrosorbide	Italy
Risordan	France
Sorbidilat	Switzerland
Zanisor	Mexico

References

Injection

References : Isosorbide dinitrate

	Type	Publication
190	Journal	Lee MG. Sorption of four drugs to polyvinyl chloride and polybutadiene intravenous administration sets. Am J Hosp Pharm 1986 ; 43: 1945-1950.
350	Journal	Martens HJ, De Goede PN, Van Loenen AC. Sorption of various drugs in polyvinyl chloride, glass, and polyethylene-lined infusion containers. Am J Hosp Pharm 1990 ; 47: 369-373.
1067	Journal	Zeidler C, Dettmering D, Schrammel W, Spieteller M. Compatibility of various drugs used in intensive care medicine in polyethylene, PVC and glass infusion containers. EJHP 1999 ; 5: 106-110.
1102	Journal	Cossum PA, Roberts MS. Availability of isosorbide dinitrate, diazepam and chlormethiazole, from i.v. delivery systems. Eur J Clin Pharmacol 1981 ; 19: 181-185.
1147	Journal	De Muynck C, Colardyn F, Remon JP. Influence of intravenous administration set composition on the sorption of isosorbide dinitrate. J Pharm Pharmacol 1991 ; 43: 601-604.
1148	Journal	De Muynck C, Remon JP, Colardyn F. The sorption of isosorbide dinitrate to intravenous delivery systems. J Pharm Pharmacol 1988 ; 40: 601-604.
1161	Journal	Allwood MC. Sorption of parenteral nitrates during administration with a syringe pump and extension set. Int J Pharm 1987 ; 39: 183-188.
1232	Journal	Beatson C, Taylor A. A physical compatibility study of furosemide & flucloxacillin injections. Br J Pharm Pract 1987 ; 9: 223-226, 236.
1332	Journal	Lee MG, Fenton-May V. Absorption of isosorbide dinitrate by PVC infusion bags and administration sets. J Clin Hosp Pharm 1981 ; 6: 209-211.
1468	Journal	Sautou V, Chopineau J, Gremeau I, Chevrier R, Bruneaux F. Compatibility with medical plastics and stability of continuously and simultaneously infused isosorbide dinitrate and heparin. Int J Pharm 1994 ; 107: 111-119.
2141	Journal	Barinian N, Chanteux H, Viaene E, Servais H, Tulkens PM. Stability and compatibility study of cefepime in comparaison with ceftazidime for potential administration by continuous infusion under conditions pertinent to ambulatory treatment of cystic fibrosis patients and to administration in intensive care units. J Antimicrob Chemother 2003 ; 51: 651-658.
2231	Journal	de Jongh R, Hens R, Basma V, mouton JW, Tulkens PM, Carryn S. Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection. J Antimicrob Chemother 2008 ; 61, 2: 382-388.
3385	Journal	Raverdi V, Ampe E, Hecq JD, Tulkens PM. Stability and compatibility of vancomycin for administration by continuous infusion. J Antimicrob Chemother 2013 ; 68: 1179-1182.
4374	Journal	Lardinois B, Dimitriou A, Delcave C, Soumoy L, Jamart J, Bihin B, Hecq J-H, Galanti L.M. Long-term Physicochemical Stability of Concentrated Solutions of Isosorbide Dinitrate in Polypropylene Syringes for Administration in the Intensive Care Unit. Int J Pharm Compound 2020 ;24,1:64-68
4698	Journal	Ayari G, D'Huart E, Vigneron J, Demoré B. Y-site compatibility of intravenous medications commonly used in intensive care units : laboratory tests on 75 mixtures involving nine main drugs. Pharmaceutical Technology in Hospital Pharmacy 2022

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