Last update :
10/07/2024
References   References 440  
Type : Journal

Research teams : Oklahoma City - University of Oklahoma Health Sciences Center, College of Pharmacy
Authors : Stiles ML, Tu YH, Allen LV.
Title : Stability of cefazolin sodium, cefoxitin sodium, ceftazidime, and penicillin G sodium in portable pump reservoirs.
Reference : Am J Hosp Pharm ; 46: 1408-1412. 1989

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Gas chromatography
Other methods : 
Search of DEHP 
Comments : 
No comments for the degradation products
Increased concentration unexplained
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
injectionCefazolin sodium Antibiotic
Stability in solutions Polyvinyl chloride Water for Injection 73,2 mg/ml -20°C Protect from light
30 Day
injectionCefoxitin sodium Antibiotic
Stability in solutions Polyvinyl chloride Water for Injection 40 mg/ml -20°C Protect from light
30 Day
injectionCeftazidime Antibiotic
Stability in solutions Polyvinyl chloride Water for Injection 36,6 mg/ml -20°C Protect from light
30 Day
injectionPenicillin G sodium Antibiotic
Stability in solutions Polyvinyl chloride Water for Injection 0,18 MUI/ml -20°C Protect from light
30 Day

  Mentions Légales