Last update :
06/05/2024
References   References 3571  
Type : Journal
Web link : 10.1310/hpj4901-42

Research teams : Salt Lake City - Primary children\'s hospital, department of Pharmacy
Authors : Anderson C, Boehme S, Ouellette J, Stidham C, MacKay M.
Title : Physical and Chemical Compatibility of Injectable Acetaminophen During Simulated Y-Site Administration.
Reference : Hosp Pharm ; 49, 1: 42-47. 2014

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
InjectionAciclovir sodium Antiviral
Incompatible 5 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionCefoxitin sodium Antibiotic
Compatible 100 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionCeftriaxone disodium Antibiotic
Compatible 40 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionDiazepam Anxiolytic
Incompatible 5 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionDolasetron mesylate Antiemetic
Compatible 20 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionParacetamol 10 mg/ml + None
InjectionGranisetron hydrochloride Antiemetic
Compatible 1 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 125 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionHydromorphone hydrochloride Analgesic
Compatible 2 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionKetorolac tromethamine Anti-inflammatory
Compatible 30 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 62.5 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionMidazolam hydrochloride Anxiolytic
Compatible 5 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionMorphine sulfate Analgesic
Compatible 15 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionNalbuphine hydrochloride Antidote
Compatible 10 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionOndansetron hydrochloride Antiemetic
Compatible 2 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionParacetamol Analgesic
Incompatible 10 mg/ml + InjectionAciclovir sodium 5 mg/ml + None
Compatible 10 mg/ml + InjectionCefoxitin sodium 100 mg/ml + None
Compatible 10 mg/ml + InjectionCeftriaxone disodium 40 mg/ml + None
Compatible 10 mg/ml + InjectionClindamycin phosphate 10 mg/ml + None
Compatible 10 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + None
Incompatible 10 mg/ml + InjectionDiazepam 5 mg/ml + None
Compatible 10 mg/ml + InjectionDiphenhydramine hydrochloride 50 mg/ml + None
Compatible 10 mg/ml + InjectionDolasetron mesylate 20 mg/ml + None
Compatible 10 mg/ml + InjectionFentanyl citrate 50 µg/ml + None
Compatible 10 mg/ml + InjectionGranisetron hydrochloride 1 mg/ml + None
Compatible 10 mg/ml + InjectionHydrocortisone sodium succinate 125 mg/ml + None
Compatible 10 mg/ml + InjectionHydromorphone hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + InjectionKetorolac tromethamine 30 mg/ml + None
Compatible 10 mg/ml + InjectionMethylprednisolone sodium succinate 62.5 mg/ml + None
Compatible 10 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + InjectionMorphine sulfate 15 mg/ml + None
Compatible 10 mg/ml + InjectionNalbuphine hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + InjectionOndansetron hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + InjectionPethidine hydrochloride 50 mg/ml + None
Compatible 10 mg/ml + InjectionPiperacillin sodium / tazobactam 100 mg/ml + None
Compatible 10 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + None
Compatible 10 mg/ml + InjectionVancomycin hydrochloride 5 mg/ml + None
InjectionPethidine hydrochloride Analgesic
Compatible 50 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 100 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 1 mg/ml + InjectionParacetamol 10 mg/ml + None
InjectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + InjectionParacetamol 10 mg/ml + None
Stability of mixtures
Polypropylen Syringe Water for Injection 25°C Not specified
Injection Diphenhydramine hydrochloride 50 mg/ml
Injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
Injection Granisetron hydrochloride 1 mg/ml
Injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
Injection Ketorolac tromethamine 30 mg/ml
Injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
Injection Nalbuphine hydrochloride 10 mg/ml
Injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
Injection Ondansetron hydrochloride 2 mg/ml
Injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
Injection Vancomycin hydrochloride 5 mg/ml
Injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
Injection Piperacillin sodium / tazobactam 90/10 mg/ml
Injection Paracetamol 10 mg/ml
4 Hour
Polypropylen Syringe Water for Injection 25°C Not specified
Injection Ceftriaxone disodium 40 mg/ml
Injection Paracetamol 10 mg/ml
4 Hour

  Mentions Légales