Last update :
17/04/2024
References   References 2355  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=720

Research teams : Nagoya - Meijo University, Faculty of Pharmacy
Authors : Inagaki K, Miyamoto Y, Kurata N, Nakane S, Gill M.A, Nishida M.
Title : Stability of ranitidine hydrochloride with cefazolin sodium, cefbuperazone sodium, cefoxitin sodium nd cephalotin sodium during simulated Y-site administration.
Reference : Int J Pharm Compound ; 4, 2: 150-153. 2000

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products
Stability indicating capability inadequately assessed

List of drugs
InjectionCefalotin sodium Antibiotic
Compatible 10 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + InjectionRanitidine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 1 mg/ml + InjectionCefalotin sodium 10 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionCefalotin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionCefazolin sodium 20 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionCefoxitin sodium 20 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 25°C
Injection Ranitidine hydrochloride 0,5 mg/ml
Injection Cefazolin sodium 20 mg/ml
4 Hour

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