Bibliographie - 2355 - Stabilis 4.0

Last update :
07/10/2024

References 2355

Type :

Journal

Web link :

http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=720

Research teams :

Nagoya - Meijo University, Faculty of Pharmacy

Authors :

Inagaki K, Miyamoto Y, Kurata N, Nakane S, Gill M.A, Nishida M.

Title :

Stability of ranitidine hydrochloride with cefazolin sodium, cefbuperazone sodium, cefoxitin sodium nd cephalotin sodium during simulated Y-site administration.

Reference :

Int J Pharm Compound ; 4, 2: 150-153. 2000

Level of Evidence :

Physical stability :

Chemical stability :

High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)

Stability defined as 90% of the initial concentration

Other methods :

Comments :

No comments for the degradation products

Stability indicating capability inadequately assessed

List of drugs

Cefalotin sodium

	10 mg/ml	+ Ranitidine hydrochloride	1 mg/ml	+
	20 mg/ml	+ Ranitidine hydrochloride	1 mg/ml	+

Cefazolin sodium

20 mg/ml

Ranitidine hydrochloride

1 mg/ml

Cefoxitin sodium

20 mg/ml

Ranitidine hydrochloride

1 mg/ml

Ranitidine hydrochloride

1 mg/ml	+ Cefalotin sodium	10 mg/ml	+
1 mg/ml	+ Cefalotin sodium	20 mg/ml	+
1 mg/ml	+ Cefazolin sodium	20 mg/ml	+
1 mg/ml	+ Cefoxitin sodium	20 mg/ml	+

25°C

Ranitidine hydrochloride	0,5 mg/ml
Cefazolin sodium	20 mg/ml

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