Last update :
10/07/2024
References   References 1651  
Type : Journal

Research teams : Nimes - Caremeau Hospital, Pharmacy Department
Authors : Ars?ne M, Favetta P, Favier B, Bureau J.
Title : Comparison of ceftazidime degradation in glass bottles and plastic bags under various conditions.
Reference : J Clin Pharm Ther ; 27: 205-209. 2002

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
No visual inspection
Degradation products identified and quantified

List of drugs
injectionCeftazidime Antibiotic
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Glass NaCl 0,9% or Glucose 5% 40 mg/ml 20°C Not specified
20 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 40 mg/ml 35°C Not specified
20 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 40 mg/ml 20°C Not specified
20 Hour
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 40 mg/ml 20°C Not specified
20 Hour

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