Last update :
23/11/2022
References   References 4664  
Type : Journal
Web link : https://doi.org/10.1002/bmc.5340

Research teams : Innsbruck - Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University of Innsbruck
Authors : Harder M, Fiegl-Lechner A, Oberacher H, Horvath U.E.I, Schlager A, Jeske M, Kerndler S, Schüllner F, Bonn G.F, Rainer M.
Title : Stability evaluation of morphine, hydromorphone, metamizole and esketamine containing analgesic mixtures applied for patient-controlled analgesia in hospice and palliative care.
Reference : Biomed Chromatogr ;e5340. 2022

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
No visual inspection
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products quantified but not identified

List of drugs
InjectionEsketamine General anesthetic
InjectionHydromorphone hydrochloride Analgesic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 20 mg/ml 22°C Not specified
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 20 mg/ml 37°C Not specified
7 Day
InjectionMetamizol sodium Analgesic
InjectionMorphine hydrochloride Analgesic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 25 mg/ml 22°C Not specified
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 25 mg/ml 37°C Not specified
7 Day
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 22°C Not specified
Injection Hydromorphone hydrochloride 20 mg/ml
Injection Esketamine 20 mg/ml
7 Day
Polyvinyl chloride Sodium chloride 0,9% 22°C Not specified
Injection Morphine hydrochloride 25 mg/ml
Injection Esketamine 20 mg/ml
Injection Metamizol sodium 50 mg/ml
7 Day
Polyvinyl chloride Sodium chloride 0,9% 22°C Not specified
Injection Morphine hydrochloride 25 mg/ml
Injection Metamizol sodium 50 mg/ml
7 Day
Polyvinyl chloride Sodium chloride 0,9% 37°C Not specified
Injection Hydromorphone hydrochloride 20 mg/ml
Injection Esketamine 20 mg/ml
7 Day

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