Last update :
22/10/2020
Antiepileptic   Fosphenytoin sodium  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Incompatibilities Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Cerebryx Canada, United States of America
Fosphen India
Fostoin Japan
Pro - Epanutin Austria, Denmark, Finland, Great Britain, Iceland, Ireland, Japan, Luxembourg, Netherlands, Norway, Sweden
Prodilantin Austria, Belgium, Denmark, Finland, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Luxembourg, Netherlands, Poland, Sweden, Switzerland, United States of America
References   Injection   References : Fosphenytoin sodium  
Type Publication
800 Journal Fischer JH, Cwik MJ, Luer MS, Sibley CB, Deyo KL.
Stability of fosphenytoin sodium with intravenous solutions in glass bottles, polyvinyl chloride bags, and polypropylene syringes.
Ann Pharmacotherapy 1997 ; 31: 553-559.
1412 Journal Brett A, Riggs RM, Webster AA, Benner KW.
Y-site stability of fosphenytoin and sodium phenobarbital.
Int J Pharm Compound 1999 ; 3: 64-66.
1419 Journal Riggs RM, English BA, Webster AA, McGuire JM, Riordan JM.
Fosphenytoin Y-site stability studies with lorazepam and midazolam hydrochloride.
Int J Pharm Compound 1999 ; 3: 235-238.
1803 Journal Trissel, LA, Saenz CA, Ogundele OB, Ingram D, Baker MB.
Compatibility of fenoldopam mesylate with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2003 ; 60: 80-85.
3829 Poster So W, Kim L, Thabit A.K, Nicolau D.P, Kuti J.L.
Compatibility of isavunazonium sulfate during simulated Y-site administration.
ASHP Midyear 2015 2015
3967 Journal Staven V, Herra I, Wang S, Grönlie I,Tho I.
Physical compatibility of total parenteral nutrition and drugs in Y-site administration to children from neonates to adolescents.
J Pharm Pharmacol 2017 ;69,7:448-462
4370 Journal Staven V, Wang S, Gronlie I, Tho I.
Physical stability of an all-in one parenteral nutrition admixture for preterm infants upon mixing with micronutrients and drugs
EJHP 2018 2018;0:1-7

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