Last update :
10/08/2022
References   References 4634  
Type : Journal

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : Loeuille G, D'Huart E, Vigneron J, Nisse YE, Beiler B, Polo C, Ayari G, Sacrez M, Demoré B, Charmillon A.
Title : Stability studies of 16 Antibiotics for Continuous Infusion in Intensive Care Units and for Performing Outpatient Parenteral Antimicrobial Therapy.
Reference : Antibiotics ;11,4: 458 2022

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionAmoxicillin sodium Antibiotic
Stability in solutions Polyolefine Sodium chloride 0,9% 20 mg/ml 20-25°C Light
12 Hour
InjectionAztreonam Antibiotic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 125 mg/ml 20-25°C Light
48 Hour
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 50 mg/ml 37°C Protect from light
48 Hour
InjectionCefazolin sodium Antibiotic
Factors which affect stability Temperature 37°CNaCl 0,9% or Glucose 5% Induces Precipitation
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 125 mg/ml 20-25°C Light
24 Hour
InjectionCefepime dihydrochloride Antibiotic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 125 mg/ml 20-25°C Light
24 Hour
InjectionCefiderocol sulfate tosylate Antibiotic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 62,5 mg/mL 20-25°C Light
24 Hour
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 25 mg/mL 37°C Protect from light
6 Hour
InjectionCefoxitin sodium Antibiotic
Stability in solutions Polypropylen Syringe Glucose 5% 125 mg/ml 20-25°C Light
12 Hour
InjectionCeftazidime Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 125 mg/ml 20-25°C Light
24 Hour
Stability in solutions Polypropylen Syringe Glucose 5% 125 mg/ml 20-25°C Light
8 Hour
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 25 mg/ml 37°C Protect from light
8 Hour
InjectionCeftazidime Avibactam Antibiotic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 125/31,25 mg/ml 20-25°C Light
24 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 25/6,25 mg/ml 37°C Protect from light
12 Hour
InjectionCeftolozane / tazobactam Antibiotic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 62,5/31,25 mg/ml 20-25°C Light
48 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 25/12,5 mg/ml 37°C Protect from light
12 Hour
Stability in solutions Polyisoprene elastomer Glucose 5% 25/12,5 mg/ml 37°C Protect from light
8 Hour
InjectionCloxacillin sodium Antibiotic
Factors which affect stability Temperature 37°CNaCl 0,9% or Glucose 5% Induces Precipitation
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 125 mg/ml 20-25°C Light
24 Hour
Stability in solutions Polyisoprene elastomer Water for Injection 250 mg/ml 20-25°C Light
24 Hour
InjectionMeropenem Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 41,7 mg/ml 20-25°C Light
8 Hour
Stability in solutions Polypropylen Syringe Glucose 5% 41,7 mg/ml 20-25°C Light
4 Hour
InjectionPiperacillin sodium Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 125 mg/ml 20-25°C Light
24 Hour
Stability in solutions Polypropylen Syringe Glucose 5% 125 mg/ml 20-25°C Light
48 Hour
InjectionPiperacillin sodium / tazobactam Antibiotic
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 125/15,6 mg/ml 20-25°C Light
48 Hour
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 66,7/18,3 mg/ml 37°C Protect from light
8 Hour
Stability in solutions Polyisoprene elastomer Glucose 5% 66,7/18,3 mg/ml 37°C Protect from light
24 Hour
InjectionTemocilline Antibiotic
Stability in solutions Polyisoprene elastomer Sodium chloride 0,9% 25 mg/ml 37°C Protect from light
24 Hour
InjectionVancomycin hydrochloride Antibiotic
Stability in solutions Polypropylen Syringe Glucose 5% 62,5 >> 83,3 mg/ml 20-25°C Light
48 Hour
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 37,5 mg/ml 37°C Protect from light
48 Hour

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