Last update :
18/04/2024
References   References 301  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/54/11/1295

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Gilbert DL, Martinez JF, Baker MB, Walter WV, Mirtallo JM.
Title : Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 54: 1295-1300. 1997

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAciclovir sodium Antiviral
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 7 mg/ml + Parenteral nutrition (binary mixture)
InjectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionAminophylline Various
Compatible 2.5 mg/ml + Parenteral nutrition (binary mixture)
InjectionAmphotericin B Antifungal
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 0.6 mg/ml + Parenteral nutrition (binary mixture)
InjectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
InjectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 20/10 mg/ml + Parenteral nutrition (binary mixture)
InjectionAztreonam Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
InjectionBumetanide Diuretic
Compatible 0.04 mg/ml + Parenteral nutrition (binary mixture)
InjectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + Parenteral nutrition (binary mixture)
InjectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + Parenteral nutrition (binary mixture)
InjectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
InjectionCarboplatin Anticancer drug
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionCefazolin sodium Antibiotic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 20 mg/ml + Parenteral nutrition (binary mixture)
InjectionCefonicid sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
InjectionCefoperazone sodium Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
InjectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
InjectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
InjectionCeftazidime Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
InjectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
InjectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
InjectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + Parenteral nutrition (binary mixture)
InjectionChlorpromazine hydrochloride Anxiolytic
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
InjectionCiclosporin Immunosuppressant
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + Parenteral nutrition (binary mixture)
InjectionCiprofloxacin lactate Antibiotic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 1 mg/ml + Parenteral nutrition (binary mixture)
InjectionCisplatin Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 1 mg/ml + Parenteral nutrition (binary mixture)
InjectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
InjectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + Parenteral nutrition (binary mixture)
InjectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
InjectionCytarabine Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 50 mg/ml + Parenteral nutrition (binary mixture)
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
InjectionDigoxin Cardiotonic
Compatible 250 µg/ml + Parenteral nutrition (binary mixture)
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 & 50 mg/ml + Parenteral nutrition (binary mixture)
InjectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + Parenteral nutrition (binary mixture)
InjectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + Parenteral nutrition (binary mixture)
InjectionDoxorubicin hydrochloride Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (binary mixture)
InjectionDoxycycline hyclate Antibiotic
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
InjectionDroperidol Neuroleptic
Compatible 0.4 mg/ml + Parenteral nutrition (binary mixture)
InjectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + Parenteral nutrition (binary mixture)
InjectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
InjectionFentanyl citrate Analgesic
Compatible 12.5 & 50 µg/ml + Parenteral nutrition (binary mixture)
InjectionFluconazole Antifungal
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
InjectionFluorouracil Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 16 mg/ml + Parenteral nutrition (binary mixture)
InjectionFolinate calcium Cytoprotective
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
InjectionFurosemide Diuretic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 3 mg/ml + Parenteral nutrition (binary mixture)
InjectionGallium nitrate Calcium-lowering agent
Compatible 0.4 mg/ml + Parenteral nutrition (binary mixture)
InjectionGanciclovir sodium Antiviral
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 20 mg/ml + Parenteral nutrition (binary mixture)
InjectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionGranisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + Parenteral nutrition (binary mixture)
InjectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + Parenteral nutrition (binary mixture)
InjectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + Parenteral nutrition (binary mixture)
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
InjectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + Parenteral nutrition (binary mixture)
InjectionHydroxyzine dihydrochloride Anxiolytic
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
InjectionIfosfamide Anticancer drug
Compatible 25 mg/ml + Parenteral nutrition (binary mixture)
InjectionImipenem - cilastatin sodium Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
InjectionInsulin Glucose-lowering
Compatible 1 UI/ml + Parenteral nutrition (binary mixture)
InjectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + Parenteral nutrition (binary mixture)
InjectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + Parenteral nutrition (binary mixture)
InjectionMannitol Various
Compatible 150 mg/ml + Parenteral nutrition (binary mixture)
InjectionMesna Cytoprotective
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
InjectionMethotrexate sodium Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 15 mg/ml + Parenteral nutrition (binary mixture)
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionMetoclopramide hydrochloride Antiemetic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionMidazolam hydrochloride Anxiolytic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (binary mixture)
InjectionMinocycline hydrochloride Antibiotic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 0.2 mg/ml + Parenteral nutrition (binary mixture)
InjectionMitoxantrone dihydrochloride Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 0.5 mg/ml + Parenteral nutrition (binary mixture)
InjectionMorphine sulfate Analgesic
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
InjectionNafcillin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (binary mixture)
InjectionNalbuphine hydrochloride Antidote
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
InjectionNetilmicin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionNitroglycerin Vasodilator
Compatible 0.4 mg/ml + Parenteral nutrition (binary mixture)
InjectionNitroprusside sodium Vasodilator
Compatible 0.4 mg/ml + Parenteral nutrition (binary mixture)
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.016 mg/ml + Parenteral nutrition (binary mixture)
InjectionOctreotide acetate Various
Compatible 0.010 mg/ml + Parenteral nutrition (binary mixture)
InjectionOfloxacin Antibiotic
Compatible 4 mg/ml + Parenteral nutrition (binary mixture)
InjectionOndansetron hydrochloride Antiemetic
Compatible 1 mg/ml + Parenteral nutrition (binary mixture)
InjectionPaclitaxel Anticancer drug
Compatible 1.2 mg/ml + Parenteral nutrition (binary mixture)
InjectionPentobarbital sodium General anesthetic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + Parenteral nutrition (binary mixture)
InjectionPhenobarbital sodium Antiepileptic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (binary mixture)
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 40/5 mg/ml + Parenteral nutrition (binary mixture)
InjectionPotassium chloride Electrolyte
Compatible 100 mEq/l + Parenteral nutrition (binary mixture)
InjectionPotassium phosphate Electrolyte
Incompatible 3 mmol/ml + Parenteral nutrition (binary mixture)
InjectionProchlorperazine edysilate Neuroleptic
Compatible 0.5 mg/ml + Parenteral nutrition (binary mixture)
InjectionPromethazine hydrochloride Antihistamine (H1)
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (binary mixture)
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
InjectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + Parenteral nutrition (binary mixture)
InjectionSodium Phosphate Electrolyte
Incompatible 1 mmol/ml + Parenteral nutrition (binary mixture)
InjectionTacrolimus Immunosuppressant
Compatible 1000 µg/ml + Parenteral nutrition (binary mixture)
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + Parenteral nutrition (binary mixture)
InjectionTobramycin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (binary mixture)
InjectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (binary mixture)
InjectionZidovudine Antiviral
Compatible 4 mg/ml + Parenteral nutrition (binary mixture)

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