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28/04/2024
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Antibiotic   Ceftolozane / tazobactam  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Zepilen Spain
Zerbaxa Argentina, Chile, Ecuador, France, Germany, Great Britain, Mexico, Peru, Romania, Spain, Switzerland, United States of America
Compatibility   Injection   Compatibility : Ceftolozane / tazobactam              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Chemical instability Incompatible
Injection Ceftolozane / tazobactam
Injection Amikacin sulfate
3549
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Amikacin sulfate 5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Amiodarone hydrochloride 2 mg/ml
NaCl 0,9% or Glucose 5% 3828
Immediate turbidity Incompatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Amphotericin B 0.1 mg/ml
Glucose 5% 3828
Immediate turbidity Incompatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Amphotericin B lipid complex 1 mg/ml
Glucose 5% 3828
Immediate turbidity Incompatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Amphotericin B liposomale 2 mg/ml
Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Ampicillin sodium - sulbactam sodium 20/10 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Anidulafungin 0.77 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Azithromycine 2 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Aztreonam 20 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Bumetanide 0.25 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Calcium chloride 20 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Calcium gluconate 20 mg/ml
NaCl 0,9% or Glucose 5% 3828
Immediate turbidity Incompatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Caspofungin acetate 0.5 mg/ml
Sodium chloride 0,9% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Cefazolin sodium 20 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Cefepime dihydrochloride 40 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 15 mg/ml
Injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Ceftaroline fosamil 12 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Ceftazidime 40 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Ceftriaxone disodium 40 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Cefuroxime sodium 30 mg/ml
NaCl 0,9% or Glucose 5% 3828
Immediate turbidity Incompatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Ciclosporin 5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Ciprofloxacin lactate 2 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Cisatracurium besylate 0.4 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Colistin mesilate sodium 4.5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Daptomycin 10 mg/ml
Sodium chloride 0,9% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Dexamethasone sodium phosphate 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Dexmedetomidine 4 µg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Digoxin 250 µg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Diltiazem hydrochloride 5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Diphenhydramine hydrochloride 50 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Dobutamine hydrochloride 4 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Dopamine hydrochloride 0.8 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Doripenem 4.5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Doxycycline hyclate 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Epinephrine hydrochloride 16 µg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Eptifibatide 2 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 20/10 mg/ml
Injection Eravacycline 0,6 mg/ml
Sodium chloride 0,9% 4434
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Ertapenem 20 mg/ml
Sodium chloride 0,9% 3828
Unspecified incompatibility Incompatible
Injection Ceftolozane / tazobactam
Injection Erythromycin lactobionate
3674
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Esmolol hydrochloride 10 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Esomeprazole sodium 0.8 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Famotidine 4 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Fentanyl citrate 50 µg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Filgrastim 15 µg/ml
Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 20/10 mg/ml
Injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Furosemide 3 mg/ml
NaCl 0,9% or Glucose 5% 3828
Unspecified incompatibility Incompatible
Injection Ceftolozane / tazobactam
Injection Gentamicin sulfate
3643
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Gentamicin sulfate 5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Unspecified incompatibility Incompatible
Injection Ceftolozane / tazobactam
Injection Gentamicin sulfate
3520
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Heparin sodium 1000 UI/ml
NaCl 0,9% or Glucose 5% 3828
Immediate turbidity Incompatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Human albumin 250 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Hydrocortisone sodium succinate 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Hydromorphone hydrochloride 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Imipenem - cilastatin sodium 5/5 mg/ml
Sodium chloride 0,9% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Insulin 1 UI/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Labetalol hydrochloride 2 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Levofloxacine 5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Lidocaine hydrochloride 8 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Linezolid 2 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Lorazepam 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Magnesium sulfate 100 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Mannitol 250 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Meropenem 10 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Mesna 20 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Methylprednisolone sodium succinate 20 mg/ml
Sodium chloride 0,9% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Metoclopramide hydrochloride 0.2 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Metronidazole 5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Micafungin 2 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Midazolam hydrochloride 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Milrinone lactate 0.2 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Morphine sulfate 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Mycophenolate mofetil 6 mg/ml
Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Naloxone hydrochloride 0.04 mg/ml
NaCl 0,9% or Glucose 5% 3828
Immediate precipitation Incompatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Nicardipine hydrochloride 0.1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Nitroglycerin 0.4 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Nitroprusside sodium 0.4 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Norepinephrine bitartrate 0.032 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Octreotide acetate 0.004 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Ondansetron hydrochloride 0.16 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Pantoprazole sodium 0.4 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Penicillin G potassium 0.1 MUI/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Pethidine hydrochloride 10 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Phenylephrine hydrochloride 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Immediate precipitation Incompatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Phenytoin sodium 10 mg/ml
Sodium chloride 0,9% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 20/10 mg/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Potassium chloride 100 mEq/l
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Potassium phosphate 0.3 mmol/ml
NaCl 0,9% or Glucose 5% 3828
Immediate instability of the emulsion Incompatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Propofol 10 mg/ml
Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Ranitidine hydrochloride 2.5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Rocuronium bromide 5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Sodium bicarbonate 84 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Sodium Phosphate 0.5 mmol/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Tacrolimus 0.02 µg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Tigecycline 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Tobramycin sulfate 5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Vancomycin hydrochloride 5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Immediate precipitation Incompatible
Injection Ceftolozane / tazobactam 15 mg/ml
Injection Vancomycin hydrochloride 15 mg/ml
Glucose 5% 3984
Compatible
Injection Ceftolozane / tazobactam 15 mg/ml
Injection Vancomycin hydrochloride 5 & 10 mg/ml
Glucose 5% 3984
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Vasopressin 1 UI/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Ceftolozane / tazobactam 10/5 mg/ml
Injection Vecuronium bromide 1 mg/ml
NaCl 0,9% or Glucose 5% 3828
  Mentions Légales