Last update :
18/04/2024
References   References 36  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/52/21/2423

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Alex S, Gupta SL, Minor JR, Turcovski-Corrales S, Gallelli JF, Taub D, Piscitelli SC.
Title : Compatibility and activity of aldesleukin (recombinant interleukin-2) in presence of selected drugs during simulated Y-site administration: Evaluation of three methods.
Reference : Am J Health-Syst Pharm ; 52: 2423-2426. 1995

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAldesleukin Anticancer drug
Compatible 0.0338 MUI/ml + InjectionAmphotericin B 1.6 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionCalcium gluconate 100 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionCo-trimoxazole + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionDiphenhydramine hydrochloride 50 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionDopamine hydrochloride 1.6 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionFluconazole 2 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionFoscarnet sodium 24 mg/ml + Glucose 5%
Incompatible 0.0338 MUI/ml + InjectionGanciclovir sodium 10 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionHeparin sodium 100 UI/ml + Glucose 5%
Incompatible 0.0338 MUI/ml + InjectionLorazepam 2 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionMagnesium sulfate 20 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionOndansetron hydrochloride 0.7 mg/ml + Glucose 5%
Incompatible 0.0338 MUI/ml + InjectionPentamidine isetionate 6 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionPotassium chloride 200 mEq/l + Glucose 5%
Incompatible 0.0338 MUI/ml + InjectionProchlorperazine edysilate 5 mg/ml + Glucose 5%
Incompatible 0.0338 MUI/ml + InjectionPromethazine hydrochloride 25 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + InjectionRanitidine hydrochloride 1 mg/ml + Glucose 5%
InjectionAmphotericin B Antifungal
Compatible 1.6 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionCo-trimoxazole Antibiotic
Compatible + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionFoscarnet sodium Antiviral
Compatible 24 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionGanciclovir sodium Antiviral
Incompatible 10 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionLorazepam Anxiolytic
Incompatible 2 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionMagnesium sulfate Electrolyte
Compatible 20 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionOndansetron hydrochloride Antiemetic
Compatible 0.7 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionPentamidine isetionate Antibiotic
Incompatible 6 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionPotassium chloride Electrolyte
Compatible 200 mEq/l + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionProchlorperazine edysilate Neuroleptic
Incompatible 5 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionPromethazine hydrochloride Antihistamine (H1)
Incompatible 25 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 1 mg/ml + InjectionAldesleukin 0.0338 MUI/ml + Glucose 5%

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