Last update :
30/09/2022
References   References 4677  
Type : Poster

Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Linxweiler H, Thiesen J, Krämer I.
Title : Physicochemical stability of diluted "Thiotepa Riemser" infusion solutions in prefilled 5% glucose infusion bags.
Reference : EAHP Congress Vienna 2022

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
InjectionThiotepa Anticancer drug
Factors which affect stability Temperature 25°C Induces Reduced stability
Stability in solutions Polyolefine Glucose 5% 1 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyolefine Glucose 5% 1 mg/ml 25°C Light
3 Day
Stability in solutions Polyolefine Glucose 5% 2 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyolefine Glucose 5% 3 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polyolefine Glucose 5% 3 mg/ml 25°C Light
5 Day

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