Last update :
13/08/2020
References   References 4358  
Type : Journal
Web link : http://dx.doi.org/10.1016/j.annfar.2014.03.009

Research teams : Clermont-Ferrand - University Hospital Gabriel Monpied, Department of Pharmacy
Authors : Pignard J, Bourdeaux D, Kauffmann S, Constantin J.M, Sautou V.
Title : Stabilité physico-chimique des solutions injectables de bésilate de cisatracurium dans les conditions cliniques d'utilisation
Reference : Ann Fr Anesth Réanim ; 33, 5: 304-309. 2014

Level of Evidence : 
Level of evidence C+
Physical stability : 
Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Method not shown but the article refers to a validated method

List of drugs
InjectionCisatracurium besylate Curarimimetic
Stability in solutions Polyolefine Sodium chloride 0,9% 0,1 mg/ml 23-27°C Not specified
48 Hour
Stability in solutions Polyolefine Sodium chloride 0,9% 0,1 mg/ml 4-6°C Not specified
7 Day
Stability in solutions Polyolefine Glucose 5% 0,1 mg/ml 23-27°C Not specified
24 Hour
Stability in solutions Polyolefine Glucose 5% 0,1 mg/ml 4-6°C Not specified
7 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,1 mg/ml 23-27°C Not specified
2 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,1 mg/ml 4-6°C Not specified
7 Day
Stability in solutions Polypropylen Syringe Glucose 5% 0,1 mg/ml 23-27°C Not specified
2 Day
Stability in solutions Polypropylen Syringe Glucose 5% 0,1 mg/ml 4-6°C Not specified
2 Day
Stability in solutions Polypropylen Syringe None 2 mg/ml 23-27°C Not specified
7 Day
Stability in solutions Polypropylen Syringe None 2 mg/ml 4-6°C Not specified
7 Day
Stability in solutions Polypropylen Syringe None 5 mg/ml 23-27°C Not specified
7 Day
Stability in solutions Polypropylen Syringe None 5 mg/ml 4-6°C Not specified
7 Day

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