Last update :
17/04/2024
References   References 19  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/43/6/1444

Research teams : Gainesville - University of Florida, College of Pharmacy
Authors : Bell RG, Lipford LC, Massanari MJ, Riley CM.
Title : Stability of intravenous admixtures of aztreonam and cefoxitin, gentamicin, metronidazole, or tobramycin.
Reference : Am J Hosp Pharm ; 43: 1444-1453. 1986

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products not observed in real conditions

List of drugs
InjectionAztreonam Antibiotic
Compatible 10 & 20 mg/ml + InjectionCefoxitin sodium 10 & 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 10 & 20 mg/ml + InjectionGentamicin sulfate 0.2 & 0.8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 10 & 20 mg/ml + InjectionMetronidazole 5 mg/ml + None
Compatible 10 & 20 mg/ml + InjectionTobramycin sulfate 0.2 & 0.8 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCefoxitin sodium Antibiotic
Compatible 10 & 20 mg/ml + InjectionAztreonam 10 & 20 mg/ml + NaCl 0,9% or Glucose 5%
InjectionGentamicin sulfate Antibiotic
Compatible 0.2 & 0.8 mg/ml + InjectionAztreonam 10 & 20 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMetronidazole Antiparasitic
Incompatible 5 mg/ml + InjectionAztreonam 10 & 20 mg/ml + None
InjectionTobramycin sulfate Antibiotic
Compatible 0.2 & 0.8 mg/ml + InjectionAztreonam 10 & 20 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Not specified
Injection Aztreonam 10 & 20 mg/ml
Injection Gentamicin sulfate 0,2 & 0,8 mg/ml
8 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Not specified
Injection Aztreonam 10 & 20 mg/ml
Injection Cefoxitin sodium 10 & 20 mg/ml
12 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Not specified
Injection Aztreonam 10 & 20 mg/ml
Injection Tobramycin sulfate 0,2 & 0,8 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
Injection Aztreonam 10 & 20 mg/ml
Injection Tobramycin sulfate 0,2 mg/ml
7 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
Injection Tobramycin sulfate 0,2 & 0,8 mg/ml
Injection Aztreonam 10 & 20 mg/ml
7 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
Injection Aztreonam 10 & 20 mg/ml
Injection Cefoxitin sodium 10 & 20 mg/ml
7 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
Injection Aztreonam 10 & 20 mg/ml
Injection Gentamicin sulfate 0,2 & 0,8 mg/ml
24 Hour

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