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Anticancer drug   Fluorouracil  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Acoflut Mexico
Adrucil United States of America
Fivocil India
Fivoflu India, Malaysia
Fluorouracil Austria, Belgium, Brazil, Canada, Denmark, Finland, Germany, Great Britain, Greece, Hungary, Italy, Netherlands, Norway, Poland, Portugal, Saudi Arabia, Serbia, Spain, Switzerland, Turkey, United States of America
Fluorouracile France, Italy, Morocco, Tunisia
Flurablastin Denmark, Finland, Iceland, Norway, Sweden
Fluracedyl Belgium, Luxembourg, Malaysia, Netherlands
Flurox Ecuador, Mexico
Neoflur Egypt
Ribofluor Germany
Triosules Argentina
Stability of mixtures   injection   Stability of mixtures : Fluorouracil     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass NaCl 0,9% or Glucose 5% 16.7 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 16.7 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Glass NaCl 0,9% or Glucose 5% 35.8 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 7.1 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Glass NaCl 0,9% or Glucose 5% 40.8 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 4.6 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Glass Sodium chloride 0,9% 1 mg/ml
injection   Fluorouracil   
injection   Granisetron hydrochloride 0,5 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Glucose 5% 0,08 mg/ml
injection   Fluorouracil   
injection   Palonosetron hydrochloride 26 µg/ml
25°C
4 Hour
Light 2009
Level of evidence A+
Glass Ringer’s lactate solution 16.7 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 16.7 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Glass Ringer’s lactate solution 35.8 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 7.1 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Glass Ringer’s lactate solution 40.8 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 4.6 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 16 mg/ml
injection   Fluorouracil   
injection   Hydromorphone hydrochloride 0,5 mg/ml
-20°C
35 Day
Protect from light 513
Level of evidence A+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 16 mg/ml
injection   Fluorouracil   
injection   Hydromorphone hydrochloride 0,5 mg/ml
23°C
7 Day
Not specified 513
Level of evidence A+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml
injection   Fluorouracil   
injection   Hydromorphone hydrochloride 0,5 mg/ml
23°C
35 Day
Not specified 513
Level of evidence A+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 16 mg/ml
injection   Fluorouracil   
injection   Hydromorphone hydrochloride 0,5 mg/ml
32°C
3 Day
Not specified 513
Level of evidence A+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml
injection   Fluorouracil   
injection   Hydromorphone hydrochloride 0,5 mg/ml
32°C
7 Day
Not specified 513
Level of evidence A+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 & 16 mg/ml
injection   Fluorouracil   
injection   Hydromorphone hydrochloride 0,5 mg/ml
4°C
35 Day
Protect from light 513
Level of evidence A+
Polyvinyl chloride NaCl 0,9% or Glucose 5% 16.7 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 16.7 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Polyvinyl chloride NaCl 0,9% or Glucose 5% 35.8 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 7.1 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Polyvinyl chloride NaCl 0,9% or Glucose 5% 40.8 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 4.6 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Polyvinyl chloride Ringer’s lactate solution 16.7 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 16.7 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Polyvinyl chloride Ringer’s lactate solution 35.8 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 7.1 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Polyvinyl chloride Ringer’s lactate solution 40.8 mg/ml
injection   Fluorouracil   
injection   Folinate sodium 4.6 mg/ml
5-25°C
5 Day
Not specified 5029
Manufacturer's stability data
Polypropylen Syringe Sodium chloride 0,9% 1 & 2 mg/ml
injection   Fluorouracil   
injection   Mannitol 200 mg/ml
25°C
24 Hour
Light 411
Level of evidence C+
Polypropylen Syringe None 24 mg/ml
injection   Fluorouracil   
injection   Heparin sodium 960 UI/ml
37°C
7 Day
Not specified 163
Level of evidence B
Polypropylen Syringe None 24 mg/ml
injection   Fluorouracil   
injection   Heparin sodium 960 UI/ml
4°C
14 Day
Protect from light 163
Level of evidence B
  Mentions Légales