Last update :
28/04/2024
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Anticancer drug   Topotecan  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Acumil Mexico
Camtoop Mexico
Cantop India
Hycamtin Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Ecuador, Egypt, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Japan, Luxembourg, Malaysia, Netherlands, Norway, Poland, Portugal, Saudi Arabia, Spain, Sweden, Switzerland, Turkey, United Arab Emirates, United States of America, Venezuela
Oncotecan Colombia, Ecuador
Potactasol Argentina, Belgium, Germany, Norway, Romania
Tekan L Turkey
Topodria Colombia
Topokebir Argentina, Peru
Toposec Peru
Topotecan Belgium, Canada, Colombia, Germany, Great Britain, Norway, Peru, Romania, Spain
Topotel Egypt
Toranex Mexico
Tpopoxin Turkey
Viatopin Hungary
Compatibility   Injection   Compatibility : Topotecan              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
Injection Topotecan 0.056 mg/ml
Injection Carboplatin 0.9 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Cimetidine hydrochloride 5.76 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Cisplatin 0.168 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Cyclophosphamide 20 mg/ml
NaCl 0,9% or Glucose 5% 1026
Immediate turbidity Incompatible
Injection Topotecan 0.056 mg/ml
Injection Dexamethasone sodium phosphate 4 mg/ml
Sodium chloride 0,9% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Dexamethasone sodium phosphate 4 mg/ml
Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Doxorubicin hydrochloride 2 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Etoposide 0.4 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Fluorouracil 50 mg/ml
Glucose 5% 1026
Immediate turbidity Incompatible
Injection Topotecan 0.056 mg/ml
Injection Fluorouracil 50 mg/ml
Sodium chloride 0,9% 1026
Compatible
Injection Topotecan 0.1 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Topotecan 0.056 mg/ml
Injection Granisetron hydrochloride 0.02 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Ifosfamide 14.28 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Methylprednisolone sodium succinate 2.4 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Metoclopramide hydrochloride 1.72 mg/ml
NaCl 0,9% or Glucose 5% 1026
Color change Incompatible
Injection Topotecan 0.056 mg/ml
Injection Mitomycin 0.084 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Ondansetron hydrochloride 0.48 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0,1 mg/ml
Injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Compatible
Injection Topotecan 0.056 mg/ml
Injection Paclitaxel 0.54 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0,1 mg/ml
Injection Palonosetron hydrochloride 50 µg/ml
Glucose 5% 1976
Color change Incompatible
Injection Topotecan 0.1 mg/ml
Injection Pemetrexed disodium 20 mg/ml
Sodium chloride 0,9% 1953
Compatible
Injection Topotecan 0.056 mg/ml
Injection Prochlorperazine edysilate 0.192 mg/ml
NaCl 0,9% or Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Ticarcillin / clavulanic acid 47.6/1.6 mg/ml
Sodium chloride 0,9% 1026
Chemical instability Incompatible
Injection Topotecan 0.056 mg/ml
Injection Ticarcillin / clavulanic acid 47.6/1.6 mg/ml
Glucose 5% 1026
Compatible
Injection Topotecan 0.056 mg/ml
Injection Vincristine sulfate 1 mg/ml
NaCl 0,9% or Glucose 5% 1026
  Mentions Légales