Last update :
15/10/2021
Antibiotic   Penicillin G potassium  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Crystacillin Slovenia
Kristapen Turkey
Kristasil Turkey
Pen potassium Iran
Penicillin Hungary
Penicillin G Pot Turkey
Penicillina potassica Italy, Romania
Penicilline G potassium Japan, United States of America
References   Injection   References : Penicillin G potassium  
Type Publication
13 Journal Stiles ML, Allen LV.
Stability of nafcillin sodium, oxacillin sodium, penicillin G potassium, penicillin G sodium and tobramycin sulfate in polyvinyl chloride drug reservoirs.
Am J Health-Syst Pharm 1997 ; 54: 1068-1070.
73 Journal Lor E, Takagi J.
Visual compatibility of foscarnet with other injectable drugs.
Am J Hosp Pharm 1990 ; 47: 157-159.
198 Journal Gayed AA, Kheshary PR, Hinkle RL.
Visual compatibility of diltiazem injection with various diluents and medications during simulated Y-site injection.
Am J Health-Syst Pharm 1995 ; 52: 516-520.
316 Journal Veltri M, Lee CKK.
Compatibility of neonatal parenteral nutrient solutions with selected intravenous drugs.
Am J Health-Syst Pharm 1996 ; 53: 2611-2613.
317 Journal Kershaw BP, Monnier HL, Mason JH.
Visual compatibility of premixed theophylline or heparin with selected drugs for IV administration.
Am J Hosp Pharm 1993 ; 50: 1360-1362.
336 Journal Forman JK, Lachs JR, Souney PF.
Visual compatibility of acyclovir sodium with commonly used intravenous drugs during simulated Y-site injection.
Am J Hosp Pharm 1987 ; 44: 1408-1409.
371 Journal Thompson DF, Stiles ML, Allen LV, Tu YH.
Compatibility of verapamil hydrochloride with penicillin admixtures during simulated Y-site injection.
Am J Hosp Pharm 1988 ; 45: 142-145.
384 Journal Colucci RD, Cobuzzi LE, Halpern NA.
Visual compatibility of esmolol hydrochloride and various injectable drugs during simulated Y-site injection.
Am J Hosp Pharm 1988 ; 45: 630-632.
385 Journal Benedict MK, Roche VF, Banakar UV, Hilleman DE.
Visual compatibility of amiodarone hydrochloride with various antimicrobial agents during simulated Y-site injection.
Am J Hosp Pharm 1988 ; 45: 1117-1118.
386 Journal Colucci RD, Cobuzzi LE, Halpern NA.
Visual compatibility of labetalol hydrochloride injection with various injectable drugs during simulated Y-site injection.
Am J Hosp Pharm 1988 ; 45: 1357-1358.
405 Journal Nieves-Cordero AL, Luciw HM, Souney PF.
Compatibility of narcotic analgesic solutions with various antibiotics during simulated Y-site injection.
Am J Hosp Pharm 1985 ; 42: 1108-1109.
479 Journal Min DI, Brown T, HWang GC.
Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 2964-2966.
496 Journal Lor E, Sheybani T, Takagi J.
Visual compatibility of fluconazole with commonly used injectable drugs during simulated Y-site administration.
Am J Hosp Pharm 1991 ; 48: 744-746.
573 Journal Dinel BA, Ayotte DL, Behme RJ, Black BL, Whitby JL.
Stability of antibiotic admixtures frozen in minibags.
Drug Intell Clin Pharm 1977 ; 11: 542-548.
576 Journal Holmes CJ, Ausman RK, Walter CW, Kundsin RB.
Activity of antibiotic admixtures subjected to different freeze-thaw treatments.
Drug Intell Clin Pharm 1980 ; 14: 353-357.
630 Journal Das Gupta V, Stewart KR.
Stability of metronidazole and ten antibiotics when mixed with magnesium sulphate solutions.
J Clin Hosp Pharm 1985 ; 10: 67-72.
631 Journal Das Gupta V, Stewart KR.
Chemical stabilities of hydrocortisone sodium succinate and several antibiotics when mixed with metronidazole injection for intravenous infusion.
J Parenter Sci Technol 1985 ; 39: 145-148.
730 Journal Allen LV, Saul Levinson R, Phisutsinthop D.
Compatibility of various admixtures with secondary additives at Y-injection site of intravenous administration sets.
Am J Hosp Pharm 1977 ; 34: 939-943.
1035 Journal Bisaillon S, Sarrazin R.
Compatibility of several antibiotics or hydrocortisone when added to metronidazole solution for intravenous infusion.
J Parenter Sci Technol 1983 ; 37: 129-132.
1047 Journal Souney PF, Colucci RD, Mariani G, Campbell D.
Compatibility of magnesium sulfate solutions with various antibiotics during simulated Y-site injection.
Am J Hosp Pharm 1984 ; 41: 323-324.
1055 Journal Faragos S.
Compatibility of antibiotics and other drugs in total parenteral nutrition solutions.
Can J Hosp Pharm 1983 ; 36: 43-52.
1057 Journal Cutie MR.
Compatibility of verapamil hydrochloride injection with commonly used additives.
Am J Hosp Pharm 1983 ; 40: 1205-1207.
1201 Journal Yuhas EM, Lofton FT, Rosenberg HA, Mayron D, Baldinus JG.
Cimetidine hydrochloride compatibility III: Room temperature stability in drug admixtures.
Am J Hosp Pharm 1981 ; 38: 1919-1922.
1315 Journal Halpern NA, Colucci RD, Alicea M, Greenstein R.
Visual compatibility of enalaprilat with commonly used critical care medications during simulated Y-site injection.
Int J Pharm Clin Pharmacol Ther Tox 1989 ; 27: 294-297.
1490 Journal Halpern NA, Colucci RD, Alicea M, Greenstein R.
The compatibility of nicardipine hydrochloride injection with various ICU medications during simulated Y-site injection.
Int J Pharm Clin Pharmacol Ther Tox 1989 ; 27: 250-254.
3520 Manufacturer Cidomycin - Summary of product Chracteristics.
Sanofi 2011
3529 Manufacturer Ciprofloxacin – Summary of Product Characteristics
Hospira 2013
3540 Manufacturer Heparin sodium - Summary of Product Characteristics.
Wockhardt 2010
3549 Manufacturer Amikacine B Braun - Résumé des caractéristiques du produit.
B Braun 2012
3580 Manufacturer Cytarabine Accord - Résumé des caractéristiques du produit
Accord Healthcare France 2016
3588 Manufacturer Vancomycine (Vancocin®) - Résumé des caractéristiques du produit
Sandoz 2011
3594 Manufacturer Metronidazole (Flagyl®) - Summary of Product Characteristics
Zentiva 2013
3596 Manufacturer Chlorpromazine (Largactil®) - Summary of Product Characteristics
Sanofi 2014
3643 Manufacturer Gentamicin sulphate (Cidomycin®) - Summary of Product Characteristics
Sanofi 2015
3674 Manufacturer Erythromycin lactobionate - Summary of Product Characteristics
PanPharma 2016
3827 Poster Ghazi I.M, Hamada Y, Nicolau D.P.
Compatibility of tedizolid phosphate with selected intravenous drugs via simulated Y-site conditions.
ASHP Midyear 2015 2015
3828 Poster Thabit A.K, Hamada Y, Nicolau D.P.
Ceftozolane/tazobactam physical compatibility during simulated Y-site administration.
ASHP Midyear 2015 2015
3829 Poster So W, Kim L, Thabit A.K, Nicolau D.P, Kuti J.L.
Compatibility of isavunazonium sulfate during simulated Y-site administration.
ASHP Midyear 2015 2015
3931 Manufacturer Trimébutine (Débridat®) - Résumé des caractéristiques du produit
Pfizer Laboratoire 2016
4055 Journal Monogue M, Almarzoky Abuhussain S, Kuti J, Nicolau D.
Physical compatibility of fosfomycin for injection with select i.v. drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2018 , 75, 1:36-44
4145 Journal Asempa T.E, Avery L.M, Kidd J.M, Kuti J.L, Nicolau D.P.
Physical compatibility of plazomicin with select i.v. drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2018 ;75,14:1048-1056
4154 Manufacturer Bleomycin sulfate- Summary of Product Characteristics
Accord Health Care 2018
4445 Journal Reed M.D, Perry E.B, Fennell S.J, Brissie E.O, Ball W.D.
Antibiotic compatibility and stability in a parenteral nutrition solution.
Chemotherapy 1979 ; 25: 336-345.

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