Last update :
17/04/2024
References   References 630  
Type : Journal

Research teams : Houston - University of Houston, College of Pharmacy
Authors : Das Gupta V, Stewart KR.
Title : Stability of metronidazole and ten antibiotics when mixed with magnesium sulphate solutions.
Reference : J Clin Hosp Pharm ; 10: 67-72. 1985

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionAmpicillin sodium Antibiotic
Compatible 5 mg/ml + InjectionMagnesium sulfate 10 & 20 mg/ml + Sodium chloride 0,9%
InjectionCefamandole nafate Antibiotic
Compatible 5 mg/ml + InjectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
InjectionCefazolin sodium Antibiotic
Compatible 5 mg/ml + InjectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
InjectionCefoxitin sodium Antibiotic
Compatible 5 mg/ml + InjectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
InjectionMagnesium sulfate Electrolyte
Compatible 10 & 20 mg/ml + InjectionAmpicillin sodium 5 mg/ml + Sodium chloride 0,9%
Compatible 10 & 20 mg/ml + InjectionCefamandole nafate 5 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + InjectionCefazolin sodium 5 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + InjectionCefoxitin sodium 5 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + InjectionMetronidazole 2 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + InjectionMoxalactam 5 mg/ml + Glucose 5%
Compatible 10 & 20 mg/ml + InjectionNafcillin sodium 5 mg/ml + Glucose 5%
Incompatible 10 & 20 mg/ml + InjectionPenicillin G potassium + Glucose 5%
Compatible 10 & 20 mg/ml + InjectionPiperacillin sodium 5 mg/ml + Glucose 5%
InjectionMetronidazole Antiparasitic
Compatible 2 mg/ml + InjectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
InjectionMoxalactam Antibiotic
Compatible 5 mg/ml + InjectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
InjectionNafcillin sodium Antibiotic
Compatible 5 mg/ml + InjectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
InjectionPenicillin G potassium Antibiotic
Incompatible + InjectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
InjectionPiperacillin sodium Antibiotic
Compatible 5 mg/ml + InjectionMagnesium sulfate 10 & 20 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Protect from light
Injection Metronidazole 2 mg/ml
Injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
Injection Cefamandole nafate 5 mg/ml
Injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
Injection Cefazolin sodium 5 mg/ml
Injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
Injection Piperacillin sodium 5 mg/ml
Injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
Injection Cefoxitin sodium 5 mg/ml
Injection Magnesium sulfate 10 & 20 mg/ml
20 Hour
Glass Glucose 5% 25°C Protect from light
Injection Moxalactam 5 mg/ml
Injection Magnesium sulfate 10 & 20 mg/ml
20 Hour

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