Last update :
25/05/2022
References   References 13  
Type : Journal

Research teams : Oklahoma City - University of Oklahoma Health Sciences Center, College of Pharmacy
Authors : Stiles ML, Allen LV.
Title : Stability of nafcillin sodium, oxacillin sodium, penicillin G potassium, penicillin G sodium and tobramycin sulfate in polyvinyl chloride drug reservoirs.
Reference : Am J Health-Syst Pharm ; 54: 1068-1070. 1997

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
No visual inspection
Degradation products detected but not quantified

List of drugs
InjectionNafcillin sodium Antibiotic
Stability in solutions Polyvinyl chloride Water for Injection 20 & 120 mg/ml 25°C Not specified
3 Day
Stability in solutions Polyvinyl chloride Water for Injection 20 & 120 mg/ml 5°C Protect from light
14 Day
InjectionOxacillin sodium Antibiotic
Stability in solutions Polyvinyl chloride Water for Injection 120 mg/ml 25°C Not specified
3 Day
Stability in solutions Polyvinyl chloride Water for Injection 120 mg/ml 5°C Protect from light
14 Day
InjectionPenicillin G potassium Antibiotic
Stability in solutions Polyvinyl chloride Water for Injection 0,1 & 0,2 MUI/ml 25°C Not specified
3 Day
Stability in solutions Polyvinyl chloride Water for Injection 0,2 MUI/ml 5°C Protect from light
14 Day
InjectionPenicillin G sodium Antibiotic
Stability in solutions Polyvinyl chloride Water for Injection 0,1 & 0,2 MUI/ml 25°C Not specified
3 Day
InjectionTobramycin sulfate Antibiotic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 10 mg/ml 25°C Not specified
3 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 10 mg/ml 5°C Protect from light
14 Day

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