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References   References 889  
Type : Journal
Web link : https://pubmed.ncbi.nlm.nih.gov/1749709/
Research teams : Sittard - Maasland Hospital, Department of Clinical Pharmacy
Authors : Janknegt R, Stratermans T, Cilissen J, Lohman JJHM, Hooymans PM.
Title : Ofloxacin intravenous. Compatibility with other antibacterial agents.
Reference : Pharm Weekbl [Sci] ; 13: 207-209. 1991
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products
Increased concentration unexplained
List of drugs
injectionAmoxicillin sodium Antibiotic
Compatible 10 mg/ml + injectionOfloxacin 2 mg/ml + None
injectionAmoxicillin sodium / clavulanic acid Antibiotic
Compatible 12 mg/ml + injectionOfloxacin 2 mg/ml + None
injectionCeftazidime Antibiotic
Compatible 10 mg/ml + injectionOfloxacin 2 mg/ml + None
injectionClindamycin phosphate Antibiotic
Compatible 6 mg/ml + injectionOfloxacin 2 mg/ml + None
injectionFlucloxacillin sodium Antibiotic
Incompatible 10 mg/ml + injectionOfloxacin 2 mg/ml + None
injectionGentamicin sulfate Antibiotic
Compatible 0,8 mg/ml + injectionOfloxacin 2 mg/ml + None
injectionOfloxacin Antibiotic
Compatible 2 mg/ml + injectionAmoxicillin sodium 10 mg/ml + None
Compatible 2 mg/ml + injectionAmoxicillin sodium / clavulanic acid 12 mg/ml + None
Compatible 2 mg/ml + injectionCeftazidime 10 mg/ml + None
Compatible 2 mg/ml + injectionClindamycin phosphate 6 mg/ml + None
Incompatible 2 mg/ml + injectionFlucloxacillin sodium 10 mg/ml + None
Compatible 2 mg/ml + injectionGentamicin sulfate 0,8 mg/ml + None
Compatible 2 mg/ml + injectionPiperacillin sodium 20 mg/ml + None
Compatible 2 mg/ml + injectionTobramycin sulfate 0,8 mg/ml + None
Compatible 2 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + None
injectionPiperacillin sodium Antibiotic
Compatible 20 mg/ml + injectionOfloxacin 2 mg/ml + None
injectionTobramycin sulfate Antibiotic
Compatible 0,8 mg/ml + injectionOfloxacin 2 mg/ml + None
injectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + injectionOfloxacin 2 mg/ml + None
Stability of mixtures
Glass None 25°C Not specified
injection Ofloxacin 2 mg/ml
injection Amoxicillin sodium 10 mg/ml
48 Hour
Glass None 25°C Not specified
injection Ofloxacin 2 mg/ml
injection Amoxicillin sodium / clavulanic acid 12 mg/ml
48 Hour
Glass None 25°C Not specified
injection Ofloxacin 2 mg/ml
injection Tobramycin sulfate 0,8 mg/ml
48 Hour
Glass None 25°C Not specified
injection Ofloxacin 2 mg/ml
injection Gentamicin sulfate 0,8 mg/ml
48 Hour
Glass None 25°C Not specified
injection Ofloxacin 2 mg/ml
injection Clindamycin phosphate 6 mg/ml
48 Hour
Glass None 25°C Not specified
injection Ofloxacin 2 mg/ml
injection Vancomycin hydrochloride 5 mg/ml
48 Hour
Glass None 25°C Not specified
injection Ofloxacin 2 mg/ml
injection Ceftazidime 10 mg/ml
48 Hour
Glass None 25°C Not specified
injection Ofloxacin 2 mg/ml
injection Piperacillin sodium 20 mg/ml
48 Hour
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