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References   References 619  
Type : Journal
Research teams : Brooklyn - Long Island University, Arnold and Marie Schwarz College of Pharmacy
Authors : Kirschenbaum HL, Aronoff W, Perentesis GP, Plitz GW, Cutie AJ.
Title : Stability and compatibility of lidocaine hydrochloride with selected large-volume parenterals and drugs additives.
Reference : Am J Hosp Pharm ; 39: 1013-1015. 1982
Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
ultraviolet spectrometry
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Method not shown but the article refers to a validated method
Stability indicating capability inadequately assessed
List of drugs
injectionAminophylline Various
Compatible 1 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
injectionBretylium tosilate Anti-arrhythmic
Compatible 1 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
injectionCalcium gluconate Electrolyte
Compatible 2 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
injectionDigoxin Cardiotonic
Compatible 1 µg/ml + injectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 µg/ml + injectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
injectionDopamine hydrochloride Cardiotonic
Compatible 0.8 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.8 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
injectionInsulin Glucose-lowering
Compatible 1 UI/ml + injectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
injectionLidocaine hydrochloride Local anesthetic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 2 mg/ml 25°C Light
14 Day
Stability in solutions Glass Ringer’s lactate solution 2 mg/ml 25°C Light
14 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 2 mg/ml 25°C Light
14 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 2 mg/ml 25°C Light
14 Day
Compatible + Ringer’s lactate solution
Compatible + Glucose 5%
Compatible + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionAminophylline 1 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + injectionAminophylline 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionBretylium tosilate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionBretylium tosilate 1 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + injectionCalcium gluconate 2 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + injectionCalcium gluconate 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionDigoxin 1 µg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + injectionDigoxin 1 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionInsulin 1 UI/ml + Ringer’s lactate solution
Incompatible 2 mg/ml + injectionPhenytoin sodium 1 mg/ml + Ringer’s lactate solution
Incompatible 2 mg/ml + injectionPhenytoin sodium 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionProcainamide hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionProcainamide hydrochloride 1 mg/ml + Ringer’s lactate solution
injectionPhenytoin sodium Antiepileptic
Incompatible 1 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
injectionProcainamide hydrochloride Anti-arrhythmic
Compatible 1 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + Ringer’s lactate solution
Compatible 1 mg/ml + injectionLidocaine hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
  Mentions Légales