Last update :
21/03/2023
References   References 588  
Type : Journal

Research teams : West Point - Merck and Co
Authors : O'Brien MJ, Portnoff JB, Cohen EM.
Title : Cefoxitin sodium compatibility with intravenous infusions and additives.
Reference : Am J Hosp Pharm ; 36: 33-38. 1979

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + InjectionCefoxitin sodium 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCefoxitin sodium Antibiotic
Stability in solutions Glass Water for Injection 1 & 2 & 10 & 20 mg/ml 25°C Not specified
24 Hour
Stability in solutions Glass Water for Injection 1 >> 400 mg/ml 5°C Protect from light
7 Day
Stability in solutions Glass Water for Injection 100 & 200 mg/ml -20°C Protect from light
91 Day
Stability in solutions Glass Water for Injection 100 >> 400 mg/ml 25°C Not specified
48 Hour
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 25°C Not specified
24 Hour
Stability in solutions Glass Glucose 5% 1 & 2 & 10 & 20 mg/ml 25°C Not specified
24 Hour
Stability in solutions Glass Glucose 5% 1 >> 100 mg/ml 5°C Protect from light
7 Day
Stability in solutions Glass Glucose 5% 100 mg/ml -20°C Protect from light
91 Day
Stability in solutions Glass Glucose 5% 100 mg/ml 25°C Not specified
48 Hour
Stability in solutions Glass Ringer’s lactate solution 1 & 2 & 10 & 20 mg/ml 25°C Not specified
24 Hour
Stability in solutions Glass Ringer’s lactate solution 1 & 2 & 10 & 20 mg/ml 5°C Protect from light
7 Day
Stability in solutions Glass Glucose 10% 1 mg/ml 25°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 1 mg/ml 25°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 1 mg/ml 25°C Not specified
48 Hour
Stability in solutions Polypropylen Syringe Water for Injection 100 mg/ml 25°C Not specified
24 Hour
Compatible 5 mg/ml + InjectionAmikacin sulfate 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionGentamicin sulfate 0.4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionKanamycin sulfate 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 >> 20 mg/ml + InjectionMannitol 100 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + InjectionTobramycin sulfate 0.4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + NaHCO3
InjectionGentamicin sulfate Antibiotic
Compatible 0.4 mg/ml + InjectionCefoxitin sodium 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionKanamycin sulfate Antibiotic
Compatible 5 mg/ml + InjectionCefoxitin sodium 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMannitol Various
Compatible 100 mg/ml + InjectionCefoxitin sodium 1 >> 20 mg/ml + NaCl 0,9% or Glucose 5%
InjectionTobramycin sulfate Antibiotic
Compatible 0.4 mg/ml + InjectionCefoxitin sodium 5 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Not specified NaCl 0,9% or Glucose 5% 25°C Not specified
Injection Cefoxitin sodium 5 mg/ml
Injection Gentamicin sulfate 0,4 mg/ml
24 Hour
Not specified NaCl 0,9% or Glucose 5% 25°C Not specified
Injection Cefoxitin sodium 5 mg/ml
Injection Tobramycin sulfate 0,4 mg/ml
24 Hour
Not specified NaCl 0,9% or Glucose 5% 25°C Not specified
Injection Cefoxitin sodium 5 mg/ml
Injection Amikacin sulfate 5 mg/ml
48 Hour
Not specified NaCl 0,9% or Glucose 5% 25°C Not specified
Injection Cefoxitin sodium 5 mg/ml
Injection Kanamycin sulfate 5 mg/ml
48 Hour
Not specified NaCl 0,9% or Glucose 5% 5°C Protect from light
Injection Cefoxitin sodium 5 mg/ml
Injection Amikacin sulfate 5 mg/ml
48 Hour
Not specified NaCl 0,9% or Glucose 5% 5°C Protect from light
Injection Cefoxitin sodium 5 mg/ml
Injection Gentamicin sulfate 0,4 mg/ml
48 Hour
Not specified NaCl 0,9% or Glucose 5% 5°C Protect from light
Injection Cefoxitin sodium 5 mg/ml
Injection Kanamycin sulfate 5 mg/ml
48 Hour
Not specified NaCl 0,9% or Glucose 5% 5°C Protect from light
Injection Cefoxitin sodium 5 mg/ml
Injection Tobramycin sulfate 0,4 mg/ml
48 Hour

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