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References   References 4369  
Type : Journal
Research teams : Paris - University Hospital Pitié-Salpétrière,Department of pharmacy
Authors : Sadou Yayé H, Hassani L, Secrétan PH, Babiard M, Aouati H, Bellanger A, Tilleul P, Yagoubi N, Do B, Rietveld I.
Title : Physical and chemical stability of a generic etoposide formulation as an alternative to etoposide phosphate
Reference : J Pharm Biomed Anal ;178:112896 2020
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified
List of drugs
InjectionEtoposide Anticancer drug
Factors which affect stability Temperature 4°C Induces Precipitation
Factors which affect stability Temperature -20°C Induces Precipitation
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,4 mg/ml 23-27°C Light
21 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,6 mg/ml 23-27°C Light
21 Day
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