Last update :
26/03/2024
References   References 4368  
Type : Journal
Web link : https://doi.org/10.1186/s40780-019-0154-2

Research teams : Tokyo - National Center for Child Health and Development
Authors : Saito J, Imaizumi H, Yamatani A.
Title : Physical, chemical, and microbiological stability study of diluted atropine eye drops.
Reference : J Pharm Health Care Sci ; 5: 25. 2019

Level of Evidence : 
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
Eye-dropsAtropine sulfate Antimuscarinic
Stability in solutions Plastic bottle Commercial Drug product 0,5 mg
Nitten Atropine Ophtalmic 1%®
NaCl 0.9% 5 mL
23-27°C Protect from light
180 Day
Stability in solutions Plastic bottle Commercial Drug product 5 mg
Nitten Atropine Ophtalmic 1%®
NaCl 0.9% 5 mL
23-27°C Protect from light
180 Day
Stability in solutions Plastic bottle Commercial Drug product 10,5 mg
Nitten Atropine Ophtalmic 1%®
NaCl 0.9% 5 mL
23-27°C Protect from light
180 Day
Stability in solutions Plastic bottle Commercial Drug product 25 mg
Nitten Atropine Ophtalmic 1%®
NaCl 0.9% 5 mL
23-27°C Protect from light
180 Day
Stability in solutions Plastic bottle Commercial Drug product 0,5 mg
Nitten Atropine Ophtalmic 1%®
NaCl 0.9% 5 mL
4-6°C Protect from light
180 Day
Stability in solutions Plastic bottle Commercial Drug product 5 mg
Nitten Atropine Ophtalmic 1%®
NaCl 0.9% 5 mL
4-6°C Protect from light
180 Day
Stability in solutions Plastic bottle Commercial Drug product 10,5 mg
Nitten Atropine Ophtalmic 1%®
NaCl 0.9% 5 mL
4-6°C Protect from light
180 Day
Stability in solutions Plastic bottle Commercial Drug product 25 mg
Nitten Atropine Ophtalmic 1%®
NaCl 0.9% 5 mL
4-6°C Protect from light
180 Day

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