Last update :
10/07/2024
References   References 434  
Type : Journal

Research teams : Buffalo - Millard Fillmore Hospital, Pharmacokinetic Laboratory
Authors : Goodwin SD, Nix DE, Heyd A, Wilton JH.
Title : Compatibility of ciprofloxacin injection with selected drugs and solutions.
Reference : Am J Hosp Pharm ; 48: 2166-2171. 1991

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAmikacin sulfate Antibiotic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 5 mg/ml 25°C Light
48 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 5 mg/ml 4°C Protect from light
8 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 5 mg/ml 4°C Protect from light
48 Hour
Incompatible 4 mg/ml + injectionCiprofloxacin lactate 1.5 mg/ml + NaCl 0,9% or Glucose 5%
injectionAminophylline Various
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,3 mg/ml 25°C Light
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,3 mg/ml 4°C Protect from light
48 Hour
Incompatible 1.2 mg/ml + injectionCiprofloxacin lactate 1.5 mg/ml + NaCl 0,9% or Glucose 5%
injectionCiprofloxacin lactate Antibiotic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,5 mg/ml 25°C Light
48 Hour
Incompatible 1.5 mg/ml + injectionAmikacin sulfate 4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1.5 mg/ml + injectionAminophylline 1.2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1.5 mg/ml + injectionClindamycin phosphate 7 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1.5 mg/ml + injectionGentamicin sulfate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1.5 mg/ml + injectionMetronidazole 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1.5 mg/ml + injectionTobramycin sulfate 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionClindamycin phosphate Antibiotic
Incompatible 7 mg/ml + injectionCiprofloxacin lactate 1.5 mg/ml + NaCl 0,9% or Glucose 5%
injectionGentamicin sulfate Antibiotic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 25°C Light
48 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 1 mg/ml 25°C Light
48 Hour
conflicting data
Compatible 1 mg/ml + injectionCiprofloxacin lactate 1.5 mg/ml + NaCl 0,9% or Glucose 5%
injectionMetronidazole Antiparasitic
Compatible 4 mg/ml + injectionCiprofloxacin lactate 1.5 mg/ml + NaCl 0,9% or Glucose 5%
injectionTobramycin sulfate Antibiotic
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,2 mg/ml 25°C Light
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,2 mg/ml 4°C Protect from light
48 Hour
Compatible 1 mg/ml + injectionCiprofloxacin lactate 1.5 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Ciprofloxacin lactate 1,5 mg/ml
injection Gentamicin sulfate 1 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Ciprofloxacin lactate 1,5 mg/ml
injection Tobramycin sulfate 1 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Ciprofloxacin lactate 1,5 mg/ml
injection Amikacin sulfate 1,5 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 25°C Light
injection Ciprofloxacin lactate 1,5 mg/ml
injection Metronidazole 4 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Ciprofloxacin lactate 1,5 mg/ml
injection Gentamicin sulfate 1 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Ciprofloxacin lactate 1,5 mg/ml
injection Tobramycin sulfate 1 mg/ml
48 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Ciprofloxacin lactate 1,5 mg/ml
injection Metronidazole 4 mg/ml
48 Hour
Polyvinyl chloride Sodium chloride 0,9% 4°C Protect from light
injection Ciprofloxacin lactate 1,5 mg/ml
injection Amikacin sulfate 1,5 mg/ml
48 Hour

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