Last update :
10/07/2024
References   References 432  
Type : Journal

Research teams : Salt Lake City - University of Utah Health Care, Department of Pharmacy Services
Authors : Marble DA, Bosso JA, Townsend RJ.
Title : Stability of clindamycin phosphate with aztreonam, ceftazidime sodium, ceftriaxone sodium, or piperacillin sodium in two intravenous solutions.
Reference : Am J Hosp Pharm ; 43: 1732-1736. 1986

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
injectionAztreonam Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Light
48 Hour
Compatible 20 mg/ml + injectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
injectionCeftazidime Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Light
48 Hour
Compatible 20 mg/ml + injectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
injectionCeftriaxone disodium Antibiotic
Stability in solutions Glass Sodium chloride 0,9% 20 mg/ml 25°C Light
24 Hour
Stability in solutions Glass Glucose 5% 20 mg/ml 25°C Light
48 Hour
Incompatible 20 mg/ml + injectionClindamycin phosphate 12 mg/ml + NaCl 0,9% or Glucose 5%
injectionClindamycin phosphate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 9 & 12 mg/ml 25°C Light
48 Hour
Compatible 9 mg/ml + injectionAztreonam 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + injectionCeftazidime 20 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 12 mg/ml + injectionCeftriaxone disodium 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 9 mg/ml + injectionPiperacillin sodium 40 mg/ml + NaCl 0,9% or Glucose 5%
injectionPiperacillin sodium Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 40 mg/ml 25°C Light
48 Hour
Compatible 40 mg/ml + injectionClindamycin phosphate 9 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Aztreonam 20 mg/ml
48 Hour
Glass NaCl 0,9% or Glucose 5% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Piperacillin sodium 40 mg/ml
48 Hour
Glass Sodium chloride 0,9% 25°C Light
injection Clindamycin phosphate 12 mg/ml
injection Ceftriaxone disodium 20 mg/ml
8 Hour
Glass Sodium chloride 0,9% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Ceftazidime 20 mg/ml
48 Hour
Glass Glucose 5% 25°C Light
injection Clindamycin phosphate 12 mg/ml
injection Ceftriaxone disodium 20 mg/ml
1 Hour
Glass Glucose 5% 25°C Light
injection Clindamycin phosphate 9 mg/ml
injection Ceftazidime 20 mg/ml
24 Hour

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